{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:13:46Z","timestamp":1789193626682,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["70112403"],"award-info":[{"award-number":["70112403"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1530"],"award-info":[{"award-number":["SFB1530"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Targeting the colony\u2010stimulating factor 1 receptor (CSF1R) to remove tumour\u2010associated macrophages is being explored as cancer therapy. This strategy may be relevant for chronic lymphocytic leukaemia (CLL), which strongly depends on support from myeloid cells. However, it is unclear how CSF1R expression affects the CLL microenvironment and leukaemic progression. To examine this question, we created\n                    <jats:italic>E\u03bc\u2010TCL1<\/jats:italic>\n                    transgenic mice for CLL with\n                    <jats:italic>Csf1r<\/jats:italic>\n                    haploinsufficiency to investigate changes in myeloid cells, Csf1r expression and leukaemia progression.\n                    <jats:italic>Csf1r<\/jats:italic>\n                    haploinsufficiency reduced Csf1r expression on circulating monocytes, but did not significantly impair its expression in tissue macrophages or change the overall numbers of monocytes or macrophages in blood and lymphoid tissues.\n                    <jats:italic>E\u03bc\u2010TCL1<\/jats:italic>\n                    transgenic mice with lower Csf1r levels had less leukaemia during early disease, but this effect faded with disease progression, and their overall survival was similar to controls. Furthermore, in\u00a0vitro co\u2010culture demonstrates that depletion of CSF1R expression on cell lines did not affect the survival or migration of patient\u2010derived CLL cells. In summary, our results show that while the CSF1R pathway is important for maintaining the myeloid cells that support CLL, simply reducing CSF1R expression has only a limited effect on disease progression. Attempts to target the CSF1R for leukaemic therapy might benefit from a stronger depletion of macrophages or the combination with other agents.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70700","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T14:45:18Z","timestamp":1785077118000},"page":"939-952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reduced colony\u2010stimulating factor 1 receptor expression in myeloid cells has limited impact on chronic lymphocytic leukaemia progression"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8706-7053","authenticated-orcid":false,"given":"Natascha","family":"Rosen","sequence":"first","affiliation":[{"name":"Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging\u2010Associated Diseases University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2492-1619","authenticated-orcid":false,"given":"Guillermo","family":"Rodriguez\u2010Real","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging\u2010Associated Diseases University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6910-7792","authenticated-orcid":false,"given":"Alexander F.","family":"vom Stein","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging\u2010Associated Diseases University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8510-6035","authenticated-orcid":false,"given":"Luca D.","family":"Schreurs","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging\u2010Associated Diseases University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trong\u2010Hieu","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging\u2010Associated Diseases University of Cologne  Cologne Germany"},{"name":"Institute of Molecular Medicine RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8133-1001","authenticated-orcid":false,"given":"Viktoria","family":"Kohlhas","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging\u2010Associated Diseases University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3795-388X","authenticated-orcid":false,"given":"Thanh\u2010Tung","family":"Truong","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging\u2010Associated Diseases University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Koch","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging\u2010Associated Diseases University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Reinartz","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging\u2010Associated Diseases University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2024-8380","authenticated-orcid":false,"given":"Sumiya","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Institute of Inorganic and Materials Chemistry University of Cologne  Cologne Germany"},{"name":"Center for Molecular Medicine Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6564-0696","authenticated-orcid":false,"given":"Shaista","family":"Ilyas","sequence":"additional","affiliation":[{"name":"Institute of Inorganic and Materials Chemistry University of Cologne  Cologne Germany"},{"name":"Center for Molecular Medicine Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2765-2693","authenticated-orcid":false,"given":"Sanjay","family":"Mathur","sequence":"additional","affiliation":[{"name":"Institute of Inorganic and Materials Chemistry University of Cologne  Cologne Germany"},{"name":"Center for Molecular Medicine Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Reinart","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging\u2010Associated Diseases University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3249-7264","authenticated-orcid":false,"given":"Phuong\u2010Hien","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging\u2010Associated Diseases University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7425-4455","authenticated-orcid":false,"given":"Michael","family":"Hallek","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging\u2010Associated Diseases University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27546"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1989.tb04290.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2023.12.004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2024.107531"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2017.11.014"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.07.009"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.8.2655"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-529610"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-07-589069"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-284505"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.09.007"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0366-8"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-431452"},{"key":"e_1_2_10_15_1","article-title":"Comparative analysis of macrophage feeder systems reveals distinct behaviors and key transcriptional shifts in chronic lymphocytic leukemia cells via coculture","author":"Kohlhas V","year":"2025","journal-title":"bioRxiv"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.8.1796.1796"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240210206"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.1.111"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-11888-8_10"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2016.03.005"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-693887"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600997"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25191"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-3099"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.01.042"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-0855"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12071980"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102181599"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002584"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0308171"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1922788117"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2022.06.028"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114884"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00885-7"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-24-0103"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3337"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-023-06007-1"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mucimm.2024.08.007"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021857"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08902.x"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.17.6179"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.MR0519-143R"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11053-8"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.91.3.848"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130903"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.05.018"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13163949"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01757-9"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30764-0"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1845"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz163"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01201-9"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-3723"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1720948115"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.178146"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.05.013"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-0903"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001006"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-0810"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022861"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70700","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70700","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70700","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:04:02Z","timestamp":1789193042000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,26]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/bjh.70700"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70700","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,26]]},"assertion":[{"value":"2026-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}