{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:11:59Z","timestamp":1789193519640,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370205"],"award-info":[{"award-number":["82370205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"Summary<\/jats:title>\n \n While minimal residual disease (MRD) is a well\u2010recognized prognostic marker in multiple myeloma (MM), the clinical significance of dynamic MRD trajectories and MRD\u2010driven therapies remains incompletely elucidated. This retrospective study analysed serial MRD results from 231 newly diagnosed multiple myeloma (NDMM) patients who achieved \u2265 complete remission (CR). MRD negativity independently predicted superior progression\u2010free survival (PFS) (hazard ratio [HR]\u2009=\u20090.222; 95% confidence interval [CI] 0.124\u20130.400,\n p<\/jats:italic>\n \u2009<\u20090.001) and overall survival (OS) (HR\u2009=\u20090.280; 95% CI 0.097\u20130.809,\n p<\/jats:italic>\n \u2009=\u20090.019). Sustaining MRD negativity for \u22656\u2009months improved OS (\n p<\/jats:italic>\n \u2009<\u20090.001), while negativity duration \u226512\u2009months conferred dual prognostic benefits for both PFS and OS (both\n p<\/jats:italic>\n \u2009<\u20090.001). Patients with late MRD conversion (after \u226512\u2009months of negativity) had OS comparable to those with sustained negativity (\n p<\/jats:italic>\n \u2009=\u20090.339). Elevated circulating plasma cell at diagnosis (HR\u2009=\u20093.761; 95% CI 1.225\u201311.550,\n p<\/jats:italic>\n \u2009=\u20090.021), failure to achieve MRD negativity post\u2010induction (HR\u2009=\u20092.886; 95% CI 1.065\u20137.819,\n p<\/jats:italic>\n \u2009=\u20090.037), and a high abnormal PC\/BMPC% at MRD conversion (HR\u2009=\u20094.091; 95% CI 1.429\u201311.701,\n p<\/jats:italic>\n \u2009=\u20090.009) were independent risk factors for progression post\u2010conversion. These findings demonstrate the prognostic significance of sustained MRD negativity and support serial MRD monitoring as a potential basis for individualized MRD\u2010driven treatment strategies in NDMM.\n <\/jats:p>","DOI":"10.1111\/bjh.70704","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:44:56Z","timestamp":1784681096000},"page":"1101-1110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic significance of dynamic minimal residual disease trajectories in newly diagnosed multiple myeloma"],"prefix":"10.1111","volume":"209","author":[{"given":"Jiapei","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing 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