{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:12:35Z","timestamp":1789193555833,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"Summary<\/jats:title>\n \n This study investigated how cytosine\u2010cytosine\u2010adenine\u2010adenine\u2010thymine (CCAAT)\/enhancer\u2010binding protein alpha (\n CEBPA<\/jats:italic>\n ) mutation sites and types affect the prognosis of acute myeloid leukaemia (AML). It specifically analysed the clinical and genetic features of AML patients harbouring\n CEBPA<\/jats:italic>\n basic leucine zipper in\u2010frame insertion\/deletion (\n CEBPA<\/jats:italic>\n bZIP\u2010InDel\u2010inf) mutations and identified prognostic factors in this subtype. Prognostic factors in\n CEBPA<\/jats:italic>\n bZIP\u2010InDel\u2010inf subgroup were examined in depth. Overall survival (OS) and relapse\u2010free survival (RFS) censoring models were built, informative censoring was adjusted using inverse probability of censoring weighting, and stabilized weights were applied in weighted Cox regression analyses. Risk scores for OS and RFS were then developed from multivariable results. Ninety\u2010three patients with\n CEBPA<\/jats:italic>\n mutation, 56 had\n CEBPA<\/jats:italic>\n bZIP\u2010InDel\u2010inf. Compared with\n CEBPA<\/jats:italic>\n bZIP\u2010InDel\u2010inf,\n CEBPA<\/jats:italic>\n non\u2010InDel had a worse prognosis. Within the bZIP region, bZIP\u2010InDel\u2010inf also showed better outcomes than other mutation types, especially in double\u2010mutated cases. In weighted multivariate analysis, higher white blood cell count, blast cell count and M4\/M5 phenotype independently predicted worse OS, while higher variant allele frequency (VAF), colony stimulating factor 3 receptor (\n CSF3R<\/jats:italic>\n ) mutation and lower haemoglobin predicted worse RFS. These variables enabled clear OS and RFS risk stratification. CEBPA bZIP\u2010InDel\u2010inf is a favourable CEBPA\u2010mutated AML subtype. Further research is needed to elucidate the role of bZIP\u2010domain\u2010mutated proteins.\n <\/jats:p>","DOI":"10.1111\/bjh.70705","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T19:30:25Z","timestamp":1784835025000},"page":"1136-1145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CCAAT\/enhancer\u2010binding protein alpha basic leucine zipper in\u2010frame insertion\/deletion (\n \n CEBPA<\/i>\n bZIP\n <\/scp>\n \u2010\n InDel<\/scp>\n \u2010inf) defines a favourable\u2010prognosis subgroup in\n \n CEBPA<\/i>\n <\/scp>\n \u2010mutated acute myeloid leukaemia"],"prefix":"10.1111","volume":"209","author":[{"given":"Yankun","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1061-5131","authenticated-orcid":false,"given":"Yuqian","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8619-9676","authenticated-orcid":false,"given":"Kun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jirui","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiting","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2598-9387","authenticated-orcid":false,"given":"Yuping","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-2941"},{"key":"e_1_2_12_3_1","first-page":"139","article-title":"Research progress on CEBPA bZIP in\u2010frame mutations in acute myeloid leukemia","volume":"56","author":"Chen Kemin HZ","year":"2025","journal-title":"Guangzhou Med 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