{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:51:25Z","timestamp":1792158685377,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Donor selection in allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT) requires balancing donor safety and recipient survival. We aimed to identify dual\u2014association donor factors (DADFs)\u2014donor characteristics associated with both increased serious adverse events (SAEs) and inferior patient survival\u2014using umbilical cord blood (UCB) as a donor\u2010safety benchmark. This nationwide retrospective cohort study analysed Japanese registry data (2013\u20132022) including 22\u2009892 donors and 29\u2009559 recipients. Logistic regression identified donor SAE risk factors, while patient outcomes were evaluated using inverse probability of treatment weighting (IPTW)\u2010adjusted Cox models with UCB as reference. Propensity score matching (PSM) compared UCB with older donor haploidentical transplantation using post\u2010transplant cyclophosphamide (OD\u2010PTCy\u2010Haplo). Among donors, 93 (0.41%) experienced an SAE. Older donor age and female sex were independent risk factors for SAE. In IPTW\u2010adjusted analyses, allo\u2010HSCT from older haploidentical donors was associated with inferior overall survival (OS) and relapse\u2010free survival (RFS) compared with UCB. In PSM analyses of elderly high\u2010risk recipients, OD\u2010PTCy\u2010Haplo resulted in significantly worse OS and RFS than UCB. Older donor age emerged as a donor characteristic associated with increased donor SAE risk and inferior patient survival, particularly in haploidentical transplantation. UCB may offer a more favourable balance between donor safety and patient outcomes in selected high\u2010risk settings.<\/jats:p>","DOI":"10.1111\/bjh.70707","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T04:58:44Z","timestamp":1785128324000},"page":"1797-1806","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Donor age as a dual\u2010risk factor for donor safety and recipient survival in allogeneic haematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6430-8958","authenticated-orcid":false,"given":"Satoshi","family":"Nishiwaki","sequence":"first","affiliation":[{"name":"Department of Advanced Medicine Nagoya University Hospital  Nagoya 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