{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:49:33Z","timestamp":1792158573242,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Cluster of differrentiation 19 (CD19)\u2010directed therapies have significantly improved outcomes in B\u2010cell malignancies; however, relapse driven by antigen escape remains a major clinical challenge, underscoring the need for alternative therapeutic targets. The B\u2010cell activating factor receptor (BAFF\u2010R), a key regulator of B\u2010cell survival, is highly expressed in mature B\u2010cell neoplasms, but its relevance in B\u2010lymphoblastic leukaemia (B\u2010ALL) remains unclear. We assessed BAFF\u2010R expression in diagnostic and relapsed fresh B\u2010ALL samples using multi\u2010parameter flow cytometry. BAFF\u2010R was consistently expressed in most cases, albeit at lower levels than in mature B cells, and expression was retained in the majority of CD19\u2010negative relapses following CD19\u2010directed therapy. Notably, tumor protein p53 (\n                    <jats:italic>TP53<\/jats:italic>\n                    ) alterations were significantly enriched in CD19\u2010negative immune escape disease (68.8% vs. 21.7%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0006; OR\u2009=\u20097.9), yet BAFF\u2010R expression remained preserved in this high\u2010risk group. These findings establish BAFF\u2010R as a stable immunotherapeutic target in B\u2010ALL, including in CD19\u2010negative and\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010altered relapsed disease, and underscore its relevance amid ongoing early\u2010phase clinical trials of BAFF\u2010R\u2013directed chimeric antigen receptor (CAR) T\u2010cell therapy.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70708","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:41:13Z","timestamp":1784896873000},"page":"1530-1537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["B\u2010cell activating factor\n                    <scp>receptor<\/scp>\n                    expression in B\u2010lymphoblastic leukaemia: Flow cytometric analysis and implications for targeted therapy"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1928-8967","authenticated-orcid":false,"given":"Parastou","family":"Tizro","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine City of Hope Comprehensive Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9564-4498","authenticated-orcid":false,"given":"Ibrahim","family":"Aldoss","sequence":"additional","affiliation":[{"name":"Department of Hematology &amp; Hematopoietic Cell Transplantation City of Hope Comprehensive Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5964-4327","authenticated-orcid":false,"given":"Xiuli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology &amp; Hematopoietic Cell Transplantation City of Hope Comprehensive Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry W.","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Hematology &amp; Hematopoietic Cell Transplantation City of Hope Comprehensive Cancer Center  Duarte California USA"},{"name":"Toni Stephenson Lymphoma Center, Beckman Research Institute City of Hope  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyuan","family":"Dong","sequence":"additional","affiliation":[{"name":"Toni Stephenson Lymphoma Center, Beckman Research Institute City of Hope  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Arango","sequence":"additional","affiliation":[{"name":"Toni Stephenson Lymphoma Center, Beckman Research Institute City of Hope  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6657-5518","authenticated-orcid":false,"given":"Michael","family":"Palmer","sequence":"additional","affiliation":[{"name":"Toni Stephenson Lymphoma Center, Beckman Research Institute City of Hope  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1477-0786","authenticated-orcid":false,"given":"Soungchul","family":"Cha","sequence":"additional","affiliation":[{"name":"Toni Stephenson Lymphoma Center, Beckman Research Institute City of Hope  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine City of Hope Comprehensive Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3335-4775","authenticated-orcid":false,"given":"Huiyan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Computational and Quantitative Medicine City of Hope Comprehensive Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9129-3424","authenticated-orcid":false,"given":"Vinod","family":"Pullarkat","sequence":"additional","affiliation":[{"name":"Department of Hematology &amp; Hematopoietic Cell Transplantation City of Hope Comprehensive Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1464-5494","authenticated-orcid":false,"given":"Elizabeth","family":"Budde","sequence":"additional","affiliation":[{"name":"Department of Hematology &amp; Hematopoietic Cell Transplantation City of Hope Comprehensive Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3983-5908","authenticated-orcid":false,"given":"Guido","family":"Marcucci","sequence":"additional","affiliation":[{"name":"Department of Hematology &amp; Hematopoietic Cell Transplantation City of Hope Comprehensive Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7587-4035","authenticated-orcid":false,"given":"Winston","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine City of Hope Comprehensive Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorinda","family":"Soma","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine City of Hope Comprehensive Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Forman","sequence":"additional","affiliation":[{"name":"Department of Hematology &amp; 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