{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:51:08Z","timestamp":1792158668693,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370203"],"award-info":[{"award-number":["82370203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7264339"],"award-info":[{"award-number":["7264339"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>We analysed 1384 newly diagnosed multiple myeloma patients from 10 representative centres of the Chinese Myeloma Committee to provide an important modern real\u2010world reference. Survival outcomes were verified by the National Mortality Surveillance System to ensure data accuracy. The median age was 62\u2009years, confirming a younger age at onset in Chinese patients than in Western populations. Treatment patterns have evolved significantly: Lenalidomide, bortezomib and dexamethasone (RVD) became the predominant induction regimen (51.8%), and upfront autologous haematopoietic stem cell transplantation (AHSCT) rates in patients aged \u226465\u2009years rose to 40.0% (vs. 20.0% in our previous multicentre study). In a subcohort of patients from two out of the 10 sites, the median progression\u2010free survival was 44.2\u2009months. In the overall multicentre cohort, the median survival was not reached during a median follow\u2010up of 46.6\u2009months, with an estimated 4\u2010year survival rate of 66.4%. Using the 2025 International Myeloma Society (IMS) \/ International Myeloma Working Group (IMWG) Consensus Genomic Staging (CGS), 26.2% of patients were classified as high risk. Patients harbouring \u22652 CGS high\u2010risk factors (3.8%) had significantly inferior prognosis. This study validates the 2025 CGS in an Asian cohort and suggests that the widespread adoption of modern triplets is associated with improved real\u2010world survival, while highlighting the distinct poor outcomes in patients with multiple CGS risk factors.<\/jats:p>","DOI":"10.1111\/bjh.70712","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T13:53:37Z","timestamp":1785074017000},"page":"1694-1703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk stratification, treatment patterns and survival outcomes in newly diagnosed multiple myeloma patients: A real\u2010world analysis from the Chinese Myeloma Committee"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7040-9272","authenticated-orcid":false,"given":"Xuelin","family":"Dou","sequence":"first","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Hematology Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5134-7133","authenticated-orcid":false,"given":"Chunrui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1082-3030","authenticated-orcid":false,"given":"Ling","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6277-1183","authenticated-orcid":false,"given":"Yuping","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Hematology, Qingdao Hospital University of Health and Rehabilitation Science (Qingdao Municipal Hospital)  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liru","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fu Xing Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlei","family":"Qi","sequence":"additional","affiliation":[{"name":"National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and Prevention  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Peng","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wen","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinan","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Myeloma &amp; 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