{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:49:35Z","timestamp":1792158575805,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515220079"],"award-info":[{"award-number":["2024A1515220079"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515220156"],"award-info":[{"award-number":["2023A1515220156"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515220033"],"award-info":[{"award-number":["2022A1515220033"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20230807093820041"],"award-info":[{"award-number":["JCYJ20230807093820041"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Differentiating myosin heavy chain 9 (MYH9)\u2010related disease (MYH9\u2010RD) from immune thrombocytopenia (ITP) remains clinically challenging. This study utilized data\u2010independent acquisition (DIA) plasma proteomics to identify distinguishing biomarker signatures. Profiling cohorts of MYH9\u2010RD (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910), ITP (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910) and healthy controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200914) quantified 2533 proteins, revealing distinct immune and metabolic remodelling. We identified 91 MYH9\u2010RD\u2010specific and 124 ITP\u2010specific proteins, highlighting divergent organ involvement pathways. By integrating protein\u2013protein interaction networks with Boruta and Random Forest machine\u2010learning algorithms, we identified preliminary candidate biomarker panels (MYH9\u2010RD panel: von Willebrand factor [VWF], cholesteryl ester transfer protein [CETP], apolipoprotein A\u20101 [APOA1], periostin [POSTN]; ITP panel: neutrophil gelatinase\u2010associated lipocalin [NGAL], plasminogen activator inhibitor\u20101 [PAI\u20101], carboxypeptidase B2 [CPB2]) that demonstrated excellent apparent discrimination. This exploratory study provides a hypothesis\u2010generating framework, revealing fundamentally distinct molecular landscapes between congenital and acquired macrothrombocytopenia. Pending rigorous future external validation, these preliminary candidate biomarkers offer novel biological insights into the divergent pathophysiologies of MYH9\u2010RD and ITP.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70720","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T01:13:21Z","timestamp":1785201201000},"page":"1598-1609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel biomarkers for the differential diagnosis of paediatric\n                    <scp>MYH9<\/scp>\n                    \u2010related diseases and immune thrombocytopenia revealed by plasma proteomics"],"prefix":"10.1111","volume":"209","author":[{"given":"Xiaojuan","family":"Luo","sequence":"first","affiliation":[{"name":"Clinical Laboratory Shenzhen Children's Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Cao","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Shenzhen Children's Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7488-1555","authenticated-orcid":false,"given":"Ruizhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, the First Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0994-6585","authenticated-orcid":false,"given":"Weigen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, the First Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Huang","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Shenzhen Children's Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Shenzhen Children's Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4210-3510","authenticated-orcid":false,"given":"Xiaoying","family":"Fu","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Shenzhen Children's Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Defa","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Shenzhen Children's Hospital  Shenzhen Guangdong 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