{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:50:17Z","timestamp":1792158617375,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>The Grupo Argentino de Tratamiento de la Leucemia Aguda (GATLA) LH\u201005 trial evaluated positron emission tomography\u2010computed tomography (PET\u2010CT)\u2010guided ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine)\u00a0in patients with stage I\u2013IV classic Hodgkin lymphoma (cHL). A total of 563 patients with cHL stages I\u2013IV were included in the prospective, non\u2010randomized GATLA LH\u201005 trial. Patients received three cycles of ABVD followed by PET\u2010CT (PET3). Patients with PET3 Deauville score (DS) 1\u20132 discontinued treatment, DS 3\u20134 completed six ABVD with involved\u2010field radiotherapy (IFRT) and DS 5 received salvage chemotherapy. Progression\u2010free survival (PFS) and overall survival (OS) were estimated using the Kaplan\u2013Meier method. Prognostic factors for PFS were assessed using Cox regression. After a median follow\u2010up of 93.5\u2009months Interquartile Range (IQR) 54\u2013139, 5\u2010 and 10\u2010year PFS for the whole cohort were 78.9% 95% Confidence Interval (CI) 75.5\u201382.6 and 76.2% (95% CI 72.4\u201380.2) respectively. Five\u2010 and 10\u2010year OS were 95.2% (95% CI 93.3\u201397.0) and 93.7% (95% CI 91.5\u201396.0). All PET3\u2010negative patients achieved 10\u2010year PFS of 84.4%. PET3 was the strongest predictor of PFS, while disease stage had no independent prognostic significance. With extended follow\u2010up, PET\u2010CT\u2010adapted therapy after three cycles of ABVD provides durable disease control while reducing exposure to chemotherapy and radiotherapy. These results support PET\u2010CT\u2010guided treatment discontinuation in PET3\u2010negative patients across all stages of cHL.<\/jats:p>","DOI":"10.1111\/bjh.70721","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T01:45:53Z","timestamp":1786326353000},"page":"1610-1618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010term follow\u2010up of\n                    <scp>PET<\/scp>\n                    \/\n                    <scp>CT<\/scp>\n                    \u2010adapted therapy after three cycles of\n                    <scp>ABVD<\/scp>\n                    for all stages of classic Hodgkin lymphoma: Results of the\n                    <scp>GATLA LH<\/scp>\n                    \u201005 trial"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2068-3721","authenticated-orcid":false,"given":"Astrid","family":"Pavlovsky","sequence":"first","affiliation":[{"name":"Fundaleu, Hematology  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4816-7523","authenticated-orcid":false,"given":"Lorena","family":"Fiad","sequence":"additional","affiliation":[{"name":"Hospital Italiano La Plata, Hematology  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9339-996X","authenticated-orcid":false,"given":"Isolda","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Fundaleu, Hematology  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Prates","sequence":"additional","affiliation":[{"name":"Hospital Italiano La Plata, Hematology  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Kurgansky","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Doctus, Hematology  Santa Fe Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1408-1846","authenticated-orcid":false,"given":"Amalia","family":"Cerutti","sequence":"additional","affiliation":[{"name":"IDHEA Cl\u00ednica Hematol\u00f3gica, Hematology  Rosario, Santa Fe Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Sackmann","sequence":"additional","affiliation":[{"name":"Fundaleu, Hematology  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Negri","sequence":"additional","affiliation":[{"name":"Instituto Privado de Hematolog\u00eda y Hemoterapia, Hematology  Paran\u00e1 Entre R\u00edos Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Negri","sequence":"additional","affiliation":[{"name":"Instituto Privado de Hematolog\u00eda y Hemoterapia, Hematology  Paran\u00e1 Entre R\u00edos Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6320-8867","authenticated-orcid":false,"given":"Guillermina","family":"Remaggi","sequence":"additional","affiliation":[{"name":"Fundaleu, Hematology  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2153-635X","authenticated-orcid":false,"given":"Luciana","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Fundaleu, Hematology  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7570-400X","authenticated-orcid":false,"given":"Luciana","family":"Guanchiale","sequence":"additional","affiliation":[{"name":"Hospital Universitario Privado de C\u00f3rdoba, Hematology  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3545-0427","authenticated-orcid":false,"given":"Romina","family":"Mariano","sequence":"additional","affiliation":[{"name":"Hospital San Mart\u00edn, Hematology  Paran\u00e1 Entre R\u00edos, California Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Giuliani","sequence":"additional","affiliation":[{"name":"Fundaleu, Hematology  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Maradei","sequence":"additional","affiliation":[{"name":"Hospital Municipal Dr. E. Ferreyra, Hematology  Necochea, Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8589-799X","authenticated-orcid":false,"given":"Gonzalo","family":"Bentolila","sequence":"additional","affiliation":[{"name":"Fundaleu, Hematology  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2589-8190","authenticated-orcid":false,"given":"Fernando","family":"Warley","sequence":"additional","affiliation":[{"name":"Hospital Italiano Buenos Aires, Hematology  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximiliano","family":"Riddick","sequence":"additional","affiliation":[{"name":"Departamento de Matematicas NUCoMPA\u2010Facultad de Ciencias Exactas\u2010Universidad Nacional del Centro de la Provincia de Buenos Aires(UNICEN) \u2010Tandil  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Pavlovsky","sequence":"additional","affiliation":[{"name":"Fundaleu, Hematology  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15838"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.6525"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.5229"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.8800"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408648"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-02064-y"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01745"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3816\/CLML.2010.n.028"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01386"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510093"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30784-8"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32134-7"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-014-2783-x"},{"key":"e_1_2_10_15_1","first-page":"2416","article-title":"Circulating tumor DNA measurements as early outcome predictors in Hodgkin lymphoma","volume":"131","author":"Kurtz DM","year":"2018","journal-title":"Blood"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708984"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2405888"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70721","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70721","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:09:25Z","timestamp":1792156165000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,9]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/bjh.70721"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70721","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,9]]},"assertion":[{"value":"2026-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}