{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:49:32Z","timestamp":1792158572262,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Data on real\u2010world survival and treatment patterns in large, unselected myelofibrosis (MF) cohorts remain limited. We analysed 1649 patients with MF diagnosed from 2010 onwards and included in the Spanish Myelofibrosis Registry across 64 centres. Janus kinase (JAK) inhibitors were administered to approximately half of the patients. Among those aged \u226470\u2009years with intermediate\u20102\/high\u2010risk International Prognostic Scoring System (IPSS), only 25% ultimately underwent transplantation. Median survival was 6.6\u2009years, with no significant differences between primary and secondary MF; acute leukaemia was the most frequent cause of death, accounting for 20% of cases. Compared with a matched general population, relative survival at 5 and 10\u2009years was 68% and 44% respectively. The reduction in relative survival was more pronounced in patients aged &gt;65\u2009years and in male patients, two subgroups that also exhibited a higher burden of comorbidities and a greater frequency of high molecular risk mutations. Remarkably, patients in the high\u2010risk IPSS category had a 10\u2010year relative survival of only 12%; however, survival reduction was not confined to high\u2010risk disease, with divergence from expected survival emerging early among lower\u2010risk categories. These findings highlight the persistent impact of MF on life expectancy in the contemporary JAK inhibitor era and the need for improvement in its overall management.<\/jats:p>","DOI":"10.1111\/bjh.70723","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:56:23Z","timestamp":1785898583000},"page":"1715-1724","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Survival outcomes and treatment patterns in myelofibrosis in the\n                    <scp>JAK<\/scp>\n                    inhibitor era"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4289-3113","authenticated-orcid":false,"given":"Juan\u2010Carlos","family":"Hern\u00e1ndez\u2010Boluda","sequence":"first","affiliation":[{"name":"Hematology Department Hospital Cl\u00ednico Universitario\u2010INCLIVA, Universidad de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6236-7826","authenticated-orcid":false,"given":"Eduardo","family":"Arellano\u2010Rodrigo","sequence":"additional","affiliation":[{"name":"Department of Hemotherapy and Hemostasis Hospital Cl\u00ednic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9943-4404","authenticated-orcid":false,"given":"Manuel","family":"P\u00e9rez\u2010Encinas","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Cl\u00ednico Universitario, Universidad Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9\u2010Mar\u00eda","family":"Raya","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario de Canarias  Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0505-5126","authenticated-orcid":false,"given":"Mar\u00eda\u2010Teresa","family":"G\u00f3mez\u2010Casares","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario de G. 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Dr Negr\u00edn, Universidad de las Palmas de Gran Canaria, Instituto de Investigaci\u00f3n Sanitaria de Canarias (IISC)  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9520-3243","authenticated-orcid":false,"given":"Francisca","family":"Ferrer\u2010Mar\u00edn","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Morales Meseguer, Universidad Cat\u00f3lica San Antonio de Murcia, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6601-3096","authenticated-orcid":false,"given":"Alberto","family":"Hern\u00e1ndez\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario de Salamanca  Salamanca 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