{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:50:36Z","timestamp":1792158636081,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Cerebral macrovasculopathy (CV) is a major complication in children with sickle cell anaemia (SCA) and usually requires a long\u2010term transfusion programme (TP) to prevent stroke. This study aimed to identify factors predicting reversal of CV on TP in a single\u2010centre newborn cohort. Among 375 patients, 50 presented CV and received TP. Median age at diagnosis was 4.9\u2009years [3.6\u20136.1], with median follow\u2010up of 13.3\u2009years (915 patient\u2010years). Transcranial Doppler (TCD) velocities and magnetic resonance angiography (MRA) normalised in 35 patients, that is, they had reversal of CV (RCV group). Fifteen patients had no reversal of CV (No\u2010RCV group). Kaplan\u2013Meier analysis estimated that 48% (95% confidence interval [CI] [33\u201362]) still had abnormal TCD and\/or MRA 5\u2009years after diagnosis. In a multivariate Cox model, three baseline factors independently predicted CV reversal: age at CV onset, initial severity of stenosis and bronchial obstruction. Older age at diagnosis increased the likelihood of CV reversal (hazard ratio [HR] 1.31 per year, 95% CI [1.08\u20131.59],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01). In contrast, severe stenosis (HR 0.72 per 10% increase, 95% CI [0.62\u20130.85],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) and bronchial obstruction (HR 0.14, 95% CI [0.03\u20130.63],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) reduced the likelihood of CV reversal. These results suggest that, beyond TP, managing bronchial obstruction may improve vascular outcomes.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70726","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T03:01:28Z","timestamp":1786071688000},"page":"1856-1865","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of predictive factors for reversal of cerebral vasculopathy in an original longitudinal cohort study in newborns with sickle cell anaemia"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9167-6836","authenticated-orcid":false,"given":"Julie","family":"Sommet","sequence":"first","affiliation":[{"name":"INSERM U 1123 ECEVE Robert\u2010Debr\u00e9 University Hospital  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9, UMR\u2010S 1123, ECEVE  Paris France"},{"name":"Paediatric Department AP\u2010HP, Robert\u2010Debr\u00e9 University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4573-4617","authenticated-orcid":false,"given":"Priscilla","family":"Boizeau","sequence":"additional","affiliation":[{"name":"INSERM U 1123 ECEVE Robert\u2010Debr\u00e9 University Hospital  Paris France"},{"name":"Clinical Epidemiology Department AP\u2010HP, Robert\u2010Debr\u00e9 University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9636-4305","authenticated-orcid":false,"given":"Zinedine","family":"Haouari","sequence":"additional","affiliation":[{"name":"AP\u2010HP, Robert\u2010Debr\u00e9 University Hospital, Sickle Cell Disease Reference Centre  Paris 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