{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:49:32Z","timestamp":1792158572208,"version":"4.4.0"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Patients with relapsed or refractory acute myeloid leukaemia (r\/r AML) harbouring FMS\u2010like tyrosine kinase 3 (FLT3) mutations generally have poor prognosis and limited treatment options. The second\u2010generation FLT3 inhibitor gilteritinib provides better disease control compared to standard relapse therapies and was approved based on two randomized trials. We analysed its efficacy and safety in a real\u2010world cohort of r\/r AML patients undergoing gilteritinib treatment including allogeneic haematopoietic stem cell transplantation (alloHSCT). Data were collected from all consecutive r\/r AML patients with FLT3\u2010internal tandem duplication and\/or FLT3\u2010tyrosine kinase domain mutations receiving gilteritinib at 25 centres. Response and survival were analysed using descriptive and correlative statistics. A total of 156 patients were analysed, 55.1% with relapse after previous alloHSCT, and 46.2% with prior FLT3 inhibitor exposure. The overall complete remission\/incomplete remission (CR\/Cri) rate was 45.3%, with a median overall survival (OS) of 10.0\u2009months. Patients receiving gilteritinib only had a 1\u2010year OS of 34%, while those with consolidating alloHSCT had a 1\u2010year OS of 76%\u201392%, depending on gilteritinib maintenance post\u2010transplant. Resuming gilteritinib post\u2010transplant led to an 85.7% CR\/CRi rate. Our real\u2010world data confirm that gilteritinib is an effective single\u2010agent therapy for r\/r AML with FLT3 mutations, with best outcomes when used as a bridge to transplant and post\u2010transplant maintenance.<\/jats:p>","DOI":"10.1111\/bjh.70735","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:24:06Z","timestamp":1787059446000},"page":"1783-1796","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment sequence with gilteritinib and allogeneic haematopoietic stem cell transplantation in relapsed\/refractory FMS\u2010like tyrosine kinase 3 (\n                    <scp>FLT3<\/scp>\n                    )\u2010mutated acute myeloid leukaemia patients: A multicentre real\u2010world study"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8750-5308","authenticated-orcid":false,"given":"Desiree","family":"Kunadt","sequence":"first","affiliation":[{"name":"Medizinische Klinik und Poliklinik I, Universit\u00e4tsklinikum Carl Gustav Carus, TU Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1811-4562","authenticated-orcid":false,"given":"Sven","family":"Zukunft","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I, Universit\u00e4tsklinikum Carl Gustav Carus, TU Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3791-0548","authenticated-orcid":false,"given":"Christoph","family":"R\u00f6llig","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I, Universit\u00e4tsklinikum Carl Gustav Carus, TU Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Metzelder","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hematology, Oncology and Immunology Philipps University Marburg and University Hospital Gie\u00dfen and Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Burchert","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hematology, Oncology and Immunology Philipps University Marburg and University Hospital Gie\u00dfen and Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Wagner\u2010Drouet","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Pneumology University Medical Center Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3274-7390","authenticated-orcid":false,"given":"Oliver","family":"Kriege","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Pneumology University Medical Center Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1755-9583","authenticated-orcid":false,"given":"Christoph","family":"Schliemann","sequence":"additional","affiliation":[{"name":"Medizinische Klinik A, Universit\u00e4tsklinikum M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Stelljes","sequence":"additional","affiliation":[{"name":"Medizinische Klinik A, Universit\u00e4tsklinikum M\u00fcnster  M\u00fcnster 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9829-1309","authenticated-orcid":false,"given":"Normann","family":"Steiner","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology, Department of Internal Medicine V Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Nachbaur","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology, Department of Internal Medicine V Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaus","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"University Hospital Eppendorf  Hamburg Germany"},{"name":"Klinik f\u00fcr H\u00e4matologie, Universit\u00e4tsklinikum Essen  Essen 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II, Universit\u00e4tsklinikum W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4767-3275","authenticated-orcid":false,"given":"Mathias","family":"H\u00e4nel","sequence":"additional","affiliation":[{"name":"Medizinische Klinik III, Klinikum Chemnitz  Chemnitz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Schaffrath","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Martin Luther University Halle\/Wittenberg  Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3427-3632","authenticated-orcid":false,"given":"William","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"Clinic for Internal Medicine C\u2014Haematology and Oncology, Stem Cell Transplantation and Palliative Care University Medicine Greifswald  Greifswald 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W.","family":"Holderried","sequence":"additional","affiliation":[{"name":"Medical Clinic and Polyclinic III Internal Medicine With a Focus on Oncology, Hematology, and Rheumatology, University Hospital Bonn, University of Bonn  Bonn Germany"},{"name":"Division of Hematology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Reinhardt","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, and Stem Cell Transplantation Freiburg University Medical Center  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7585-8956","authenticated-orcid":false,"given":"Markus","family":"Maulhardt","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology University Medicine G\u00f6ttingen  G\u00f6ttingen 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