{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:20:15Z","timestamp":1787757615073,"version":"build-2784847793"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009447","name":"Leukemia and Lymphoma Society of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Cluster of differentiation 47 (CD47), a \u2018don't eat me\u2019 immune checkpoint receptor, is frequently overexpressed on multiple myeloma (MM) cells and contributes to immune evasion. While its immune regulatory function is well established, the intrinsic oncogenic role of CD47 remains poorly understood. Here, we demonstrate for the first time that CD47 intrinsically promotes myeloma cell proliferation and survival by activating the JAK\/STAT3\u2013MYC (Janus kinase\/signal transducer and activator of transcription 3 \u2013 MYC) signalling axis. CD47 overexpression increased cell growth, accelerated G1\u2013M\u2010cell cycle progression and promoted anchorage\u2010independent colony formation, accompanied by elevated phosphorylation of STAT3 and upregulation of\n                    <jats:italic>MYC<\/jats:italic>\n                    , whereas CD47 knockdown produced the opposite effects. Transcriptomic analysis of patient datasets revealed that high\n                    <jats:italic>CD47<\/jats:italic>\n                    expression was associated with enrichment of the JAK\u2013STAT3 and MYC pathways, and\n                    <jats:italic>CD47<\/jats:italic>\n                    levels positively correlated with\n                    <jats:italic>STAT3<\/jats:italic>\n                    and\n                    <jats:italic>MYC<\/jats:italic>\n                    expression, suggesting a potential regulatory interplay among these molecules. Pharmacological inhibition using the JAK1\/2 inhibitor ruxolitinib (Rux) decreased cell viability, induced apoptosis and suppressed STAT3 and MYC signalling. Moreover, Rux synergized with bortezomib in myeloma cell lines and primary patient samples but spared normal cells. Collectively, these findings identify CD47 as an oncogenic driver with an intrinsic signalling function in MM and highlight the CD47\u2013STAT3\u2013MYC axis as a promising therapeutic target.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70736","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T06:20:22Z","timestamp":1786774822000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CD47<\/scp>\n                    promotes myeloma cell growth through\n                    <scp>JAK<\/scp>\n                    \u2013\n                    <scp>STAT3<\/scp>\n                    \/\n                    <scp>MYC<\/scp>\n                    signalling and is targetable by ruxolitinib"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2951-4286","authenticated-orcid":false,"given":"Omar","family":"Faruq","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"},{"name":"Laboratory Medicine Program Toronto General Hospital, University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"},{"name":"Laboratory Medicine Program Toronto General Hospital, University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"},{"name":"Laboratory Medicine Program Toronto General Hospital, University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"},{"name":"Laboratory Medicine Program Toronto General Hospital, University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuihong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"},{"name":"Laboratory Medicine Program Toronto General Hospital, University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron D.","family":"Schimmer","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics University of Toronto  Toronto Ontario Canada"},{"name":"Division of Medical Oncology and Hematology Princess Margaret Cancer Centre, University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3106-2776","authenticated-orcid":false,"given":"Hong","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"},{"name":"Laboratory Medicine Program Toronto General Hospital, University Health Network  Toronto Ontario 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