{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T03:42:22Z","timestamp":1786160542476,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Peripheral T\u2010cell lymphoma, not otherwise specified (PTCL\u2010NOS), is a heterogeneous nodal T\u2010 and natural killer (NK)\u2010cell lymphoma with limited prognostic biomarkers. A subset of PTCL\u2010NOS characterized by Epstein\u2013Barr virus (EBV) involvement in tumour cells has recently been recognized as EBV\u2010positive nodal T\u2010 and NK\u2010cell lymphoma (EBV+ nPTCL), a distinct entity in the fifth edition of the World Health Organization classification of haematolymphoid neoplasms (WHO\u2010HAEM5). However, the clinical significance of circulating EBV deoxyribonucleic acid (DNA) in PTCL\u2010NOS remains unclear. Patients initially diagnosed with PTCL\u2010NOS who received first\u2010line systemic chemotherapy at a single\u2010centre between 2007 and 2025 were retrospectively analysed. Cases were reclassified according to WHO\u2010HAEM5 using EBV\u2010encoded small ribonucleic acid (EBER) in\u00a0situ hybridization and pathological review. Among 101 patients, 4 were reclassified as EBV+ nPTCL using a \u226550% tumour cell EBER positivity cut\u2010off and excluded, yielding a cohort of 97 patients with WHO\u2010HAEM5\u2013defined PTCL\u2010NOS. Baseline blood EBV\u2010DNA positivity was observed in 42.3%. EBV\u2010DNA\u2013positive patients demonstrated significantly shorter progression\u2010free and overall survival (OS) compared with EBV\u2010DNA\u2013negative patients. In multivariate analyses, EBV\u2010DNA positivity independently predicted poorer survival outcomes. Exploratory analyses indicated that EBV\u2010DNA clearance during chemotherapy was associated with improved OS. These findings suggest that blood EBV\u2010DNA may serve as a prognostic biomarker in patients with PTCL\u2010NOS.<\/jats:p>","DOI":"10.1111\/bjh.70737","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T02:44:29Z","timestamp":1786157069000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic impact of blood Epstein\u2013Barr virus\u2010\n                    <scp>DNA<\/scp>\n                    in patients with peripheral T\u2010cell lymphoma, not otherwise specified"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4502-8021","authenticated-orcid":false,"given":"Hyunseok","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Oncology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungwoo","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Oncology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6325-3548","authenticated-orcid":false,"given":"In Hye","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3679-3653","authenticated-orcid":false,"given":"Sejin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology, Department of Internal Medicine Hallym University Medical Center, Hallym University College of Medicine  Anyang\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Heun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Oncology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoungmin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Oncology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oncology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6424-9487","authenticated-orcid":false,"given":"Chan\u2010Sik","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5299-0048","authenticated-orcid":false,"given":"Eun Jin","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Radiology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1532-5970","authenticated-orcid":false,"given":"Kyung Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8339-2809","authenticated-orcid":false,"given":"Jin\u2010Sook","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2967-9670","authenticated-orcid":false,"given":"Sang\u2010Wook","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0680-4486","authenticated-orcid":false,"given":"Jaewon","family":"Hyung","sequence":"additional","affiliation":[{"name":"Department of Oncology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0412-8709","authenticated-orcid":false,"given":"Heounjeong","family":"Go","sequence":"additional","affiliation":[{"name":"Department of Pathology Asan 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JY","year":"2020","journal-title":"Front Oncol"},{"issue":"7","key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms","volume":"36","author":"Alaggio R","year":"2022","journal-title":"Leukemia"},{"issue":"11","key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1182\/blood.2022015851","article-title":"The International Consensus Classification of mature lymphoid neoplasms: a report from the Clinical Advisory Committee","volume":"140","author":"Campo E","year":"2022","journal-title":"Blood"},{"issue":"7","key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.humpath.2015.03.002","article-title":"Epstein\u2010Barr virus\u2010positive nodal T\/NK\u2010cell lymphoma: an analysis of 15 cases with distinct clinicopathological 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