{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:50:17Z","timestamp":1792158617420,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021372","name":"Hector Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021372","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Young adults (YA) are particularly affected by comorbid conditions following allogeneic haematopoietic stem cell transplantation (alloHSCT), as they have to live with them for many years. This is the first multicentre prospective study investigating sequelae after alloHSCT in YA in Germany. In total, 107 patients who survived relapse\u2010free until day 100 after alloHSCT were enrolled. Median patient age was 29.3\u2009years. Chronic graft\u2010versus\u2010host disease (cGvHD) occurred in 40.2%. Comorbidities were captured at days 100, 180, 365 and 910 by applying the post\u2010transplant multimorbidity index (PTMI). Considering all time points, 12.5%\u201323.5% of patients had no comorbidity, while 39.2%\u201349.5% had 1\u20133, 26.3%\u201333.0% had 4\u20136 and 5.7%\u20138.4% had &gt;6 PTMI\u2010defined comorbidities respectively. The most prevalent PTMI\u2010based comorbidities were iron overload, hypogonadism, arterial hypertension, infections, hepatic dysfunction and osteopenia\/osteoporosis. However, the spectrum of PTMI\u2010recorded comorbidities and those concurrently self\u2010reported by patients differed substantially. Factors linked to a higher PTMI were total body irradiation and active cGvHD. Investigating single PTMI\u2010defined comorbidities, we found significant associations of osteopenia\/osteoporosis with cGvHD, ongoing immunosuppression and hypogonadism, which was more common among female survivors. These results provide a detailed analysis of the occurrence of a vast spectrum of PTMI\u2010defined comorbidities in YA after alloHSCT.<\/jats:p>","DOI":"10.1111\/bjh.70738","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T01:12:02Z","timestamp":1786410722000},"page":"1807-1817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comorbid conditions after allogeneic haematopoietic stem cell transplantation in young adults in Germany\u2014A prospective, multicentre trial"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7263-636X","authenticated-orcid":false,"given":"Pauline","family":"Rocke","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, H\u00e4matologie und Internistische Onkologie Universit\u00e4tsklinikum Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2896-3263","authenticated-orcid":false,"given":"Lena","family":"Tandetzky","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, H\u00e4matologie und Internistische Onkologie Universit\u00e4tsklinikum Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7015-3190","authenticated-orcid":false,"given":"Daniel","family":"Wolff","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Innere Medizin III, H\u00e4matologie und Internistische Onkologie, Universit\u00e4tsklinikum Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0472-4335","authenticated-orcid":false,"given":"Katharina","family":"Egger\u2010Heidrich","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik 1, Universit\u00e4tsklinikum Carl Gustav Carus  Dresden Germany"},{"name":"DKMS Clinical Trials Unit  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Heidenreich","sequence":"additional","affiliation":[{"name":"III. Medizinische Klinik, Universit\u00e4tsmedizin Mannheim  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Schaefer\u2010Eckart","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Onkologie und H\u00e4matologie, Klinikum N\u00fcrnberg  N\u00fcrnberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Wagner\u2010Drouet","sequence":"additional","affiliation":[{"name":"III. 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