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We assessed cumulative incidence, relative risk and predictors of SPCs. We studied 521 patients diagnosed with LPL\/WM in Region Zealand, Denmark, during 2000\u20132023. Cancers diagnosed &gt;6\u2009months before or after diagnosis were classified as prior malignancies and SPCs, respectively. Cumulative incidence was estimated with death as a competing event. Standardized incidence ratios (SIRs) and absolute excess risks (AERs) used regional rates. SPC predictors were evaluated using Fine\u2013Gray and Cox models. Median age was 72\u2009years and median follow\u2010up was 8.1\u2009years. Prior malignancy was present in 64 patients (12.3%); 68 (13.1%) developed an SPC. Cumulative incidence was 9.3% at 5\u2009years and 14.6% at 10\u2009years; 166 patients (31.9%) died without a preceding SPC. With 1\u2010year latency, overall cancer risk was not increased (SIR 1.09, 95% confidence interval [CI] 0.84\u20131.40; AER 21.3 per 10\u2009000 person\u2010years). Haematological cancers showed borderline excess risk, driven by myelodysplastic syndrome. No covariates were associated with SPC risk. SPCs are clinically relevant in LPL\/WM, although excess risk appears selective rather than broadly increased. Long\u2010term surveillance should consider myeloid malignancies.<\/jats:p>","DOI":"10.1111\/bjh.70740","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T01:29:46Z","timestamp":1786325386000},"page":"1684-1693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Second primary cancers in lymphoplasmacytic lymphoma\/Waldenstr\u00f6m macroglobulinaemia\u2014cumulative burden without generalized excess cancer risk"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5553-7269","authenticated-orcid":false,"given":"Lars","family":"Munksgaard","sequence":"first","affiliation":[{"name":"Department of Hematology Zealand University Hospital  Roskilde Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9419-8841","authenticated-orcid":false,"given":"Lars Moeller","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital  Roskilde Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4377-3209","authenticated-orcid":false,"given":"Lise Mette Rahbek","family":"Gjerdrum","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Pathology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/sonc.2003.50082"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001762\u20103"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2023.03.009"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16492"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr119"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29334"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1217527"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2023.107042"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.46989\/001c.90436"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12208"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.e18893"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010022\u201003798\u20106"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.1530"},{"key":"e_1_2_12_15_1","volume-title":"NORDCAN 2.0. NORDCAN: cancer incidence, mortality, prevalence and survival in the Nordic countries, version 9.5.1 (12.02.2026)","author":"Lar\u00f8nningen S","year":"2026"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24052"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2025.06.007"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2013.05.008"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.7920"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2018.1452214"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.3128"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023011305"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26807"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70740","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70740","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:10:07Z","timestamp":1792156207000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,9]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/bjh.70740"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70740","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,9]]},"assertion":[{"value":"2026-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}