{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:49:45Z","timestamp":1792158585701,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Relapsed\/refractory extra\u2010nodal natural killer\/T\u2010cell lymphoma (R\/R ENKTL) has limited treatment options. Danburstotug, an antibody targeting programmed death\u2010ligand 1 (PD\u2010L1), was evaluated in adults with R\/R ENKTL in a phase 2, open\u2010label study (NCT04414163). Danburstotug 20\u2009mg\/kg was administered intravenously every 2\u2009weeks up to 52 cycles, disease progression or unacceptable toxicity. In the full analysis set (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200919), objective response rate (ORR; primary end\u2010point) was 78.9% (95% confidence interval 54.4\u201394.0); complete response (CR) rate was 63.2% (38.4\u201383.7); 76.9% of participants maintained responses; and 90.9% of participants maintained CR for 2\u2009years. In the intention\u2010to\u2010treat population (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200923), median progression\u2010free survival (PFS) was 29.4\u2009months (12.0\u201346.9; 2\u2010year PFS rate 62.1%); and median overall survival was 40.2\u2009months (25.1\u201355.4; 2\u2010year overall survival rate 77.9%). Treatment\u2010emergent adverse events occurred in 91.3% of 23 participants (73\/83 events were grade 1\/2); grade 3 serious treatment\u2010related adverse events comprised liver injury and uveitis (one participant each). High PD\u2010L1 membrane specificity (MS) was associated with greater ORR, CR rate and PFS versus low PD\u2010L1 MS. In tumour immune microenvironment assessments, clinical benefit was observed across immune tolerance and immune evasion subtypes, despite lower PD\u2010L1 expression in immune evasion\u2010B. Danburstotug demonstrated robust, durable efficacy and manageable safety. PD\u2010L1 MS showed potential as a predictive biomarker.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70742","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:10:38Z","timestamp":1787098238000},"page":"1638-1650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Danburstotug, an anti\u2010\n                    <scp>PD<\/scp>\n                    \u2010\n                    <scp>L1<\/scp>\n                    antibody, in relapsed\/refractory extra\u2010nodal natural killer\/T\u2010cell lymphoma: The phase 2\n                    <scp>DISTINKT<\/scp>\n                    study"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5400-0466","authenticated-orcid":false,"given":"Won Seog","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Hematology\u2010Oncology Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2776-4401","authenticated-orcid":false,"given":"Seok Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6014-7977","authenticated-orcid":false,"given":"Jae\u2010Cheol","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Ulsan University Hospital, University of Ulsan College of Medicine  Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0379-5297","authenticated-orcid":false,"given":"Sang Eun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4750-931X","authenticated-orcid":false,"given":"Youngil","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital, Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8167-8520","authenticated-orcid":false,"given":"Deok\u2010Hwan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2010Oncology Chonnam National University Hwasun Hospital, Chonnam National University Medical School  Hwasun Jeollanam\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8289-3548","authenticated-orcid":false,"given":"Dok Hyun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Oncology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6089-9340","authenticated-orcid":false,"given":"Junhun","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pathology Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0197-5256","authenticated-orcid":false,"given":"Sung Young","family":"Lee","sequence":"additional","affiliation":[{"name":"ImmuneOncia Therapeutics Inc.  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