{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:50:40Z","timestamp":1792158640795,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Watchful waiting (WW) in low tumour burden follicular lymphoma (LTB FL) defers treatment. There is a need to develop a model to predict time to treatment (TTT). We aimed to develop and externally validate a model for TTT in LTB FL. We conducted a retrospective analysis across eight centres within the Australasian Lymphoma Alliance. Two hundred and twenty\u2010nine patients were included between 2004 and 2022 with a median follow\u2010up of 5.0\u2009years (range 0.5\u201317.8\u2009years) and a median age was 64\u2009years. All patients were Group d'Etude des Lymphomes Folliculaires (GELF) negative and managed with WW. Elevated lactate dehydrogenase and &gt;4 nodal areas were independent prognostic factors associated with shorter TTT. These factors formed a prognostic model identifying three groups: low 59% (median TTT 6.34\u2009years), intermediate 36% (median TTT 4.08\u2009years), high risk 5% (median TTT 1.49\u2009years) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). There was a higher incidence of serious complications among risk groups (low 7.5% vs. intermediate 13.3% vs. high 25%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.096). The prognostic value of the LTB\u2010TREAT model was confirmed in an external validation cohort. The low\u2010risk group is predicted to have a prolonged TTT with WW and a high\u2010risk group is predicted to experience early progression in whom treatment should be considered.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70748","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:51:39Z","timestamp":1787824299000},"page":"1673-1683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>LTB<\/scp>\n                    \u2010\n                    <scp>TREAT<\/scp>\n                    : A validated international prognostic model for time to treatment in low tumour burden follicular lymphoma"],"prefix":"10.1111","volume":"209","author":[{"given":"Luani","family":"Barge","sequence":"first","affiliation":[{"name":"Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"School of Medicine University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5209-0314","authenticated-orcid":false,"given":"Lachlan","family":"Webb","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Pelecanos","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0059-1915","authenticated-orcid":false,"given":"Niamh","family":"Waters","sequence":"additional","affiliation":[{"name":"Olivia Newton John Cancer Research Institute at Austin Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1053-5503","authenticated-orcid":false,"given":"Ross","family":"Salvaris","sequence":"additional","affiliation":[{"name":"Sir Charles Gairdner Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Lai","sequence":"additional","affiliation":[{"name":"Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Potezny","sequence":"additional","affiliation":[{"name":"Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Cashman","sequence":"additional","affiliation":[{"name":"St Vincent's Hospital  Sydney New South Wales 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3685-8407","authenticated-orcid":false,"given":"Lukshe","family":"Kanagaratnam","sequence":"additional","affiliation":[{"name":"Department of Research and Innovation University Hospital of Reims, H\u00f4pital Robert Debr\u00e9  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrielle","family":"Rodier","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital of Reims, H\u00f4pital Robert Debr\u00e9  Reims France"},{"name":"UFR M\u00e9decine  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine S.","family":"Tam","sequence":"additional","affiliation":[{"name":"Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abir","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7988-1565","authenticated-orcid":false,"given":"Chan Y.","family":"Cheah","sequence":"additional","affiliation":[{"name":"Sir Charles Gairdner Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0376-2559","authenticated-orcid":false,"given":"Eliza A.","family":"Hawkes","sequence":"additional","affiliation":[{"name":"Olivia Newton John Cancer Research Institute at Austin Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2446-1098","authenticated-orcid":false,"given":"Kirk","family":"Morris","sequence":"additional","affiliation":[{"name":"Royal Brisbane and Women's Hospital  Brisbane Queensland 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