{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:50:17Z","timestamp":1792158617339,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>The Hodgkin lymphoma treatment in the elderly (eHL) is a challenge due to a narrow therapeutic window between therapy effectiveness and toxicity. Both bendamustine (Be) and brentuximab vedotin (BV) are well\u2010tolerated, effective drugs in relapsing HL, but no data exist on Be\u2010BV frontline treatment in eHL. The prospective, open\u2010label, phase I\/II Hodgkin lymphoma combining Adcetris\u00ae and Levact\u00ae in Old patients (HALO) study was launched (Clinical Trial.Gov Id. 02467946) to test safety and efficacy of Be\u2010BV in untreated eHL. The mean age was 70.75 (62\u201379), stage IIB in 12, III in 14 and IV in 31 patients. Most had B\u2010symptoms and an International Prognostic Score (IPS) \u22653 (39). Despite a good performance status and both a high activity of daily living (ADL) (\u22656 in 85%) and instrumental activities of daily living (IADL) scores (\u22658 in 77%), 68% of patients had \u22655 comorbidities, with a Cumulative Illness Rating Scale\u2010Geriatric (CIRS)\u2010G score &gt;3 in 75%. A complete metabolic response (CMR) was achieved in 44\/57 of patients. The 6\u2010year overall survival (OS) and progression\u2010free survival (PFS) in per\u2010protocol (PP) analysis were 67% (95% confidence intertvals [CI] 53\u201384) and 45% (95% CI 32\u201365) respectively. A PFS event was observed in 35: 13 progressions (10 deaths), 13 relapses (6 deaths) and 9 deaths. Be\u2010BV, when given in a full dose schedule, is an effective regimen for unselected, poor\u2010risk elderly Hodgkin lymphoma (HL) patients.<\/jats:p>","DOI":"10.1111\/bjh.70763","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:40:31Z","timestamp":1787737231000},"page":"1619-1628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010term results of brentuximab vedotin and bendamustine for first\u2010line treatment of Hodgkin lymphoma in the elderly (\n                    <scp>HALO<\/scp>\n                    trial)"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2054-7412","authenticated-orcid":false,"given":"Andrea","family":"Gallamini","sequence":"first","affiliation":[{"name":"Onco\u2010Hematology, Centre Antoine\u2010Lacassagne  Nice 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