{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T04:23:40Z","timestamp":1787372620877,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Little is known about overall and treatment\u2010related mortality (TRM) in children with non\u2010Hodgkin lymphoma (NHL) in upper\u2010middle\u2010income countries (UMICs). A retrospective cohort of children with advanced\u2010stage NHL diagnosed and treated in a large paediatric cancer centre in Shanghai, China, was analysed. The 3\u2010year overall mortality and TRM cumulative incidence were 11.20%\u2009\u00b1\u20091.44% and 2.11%\u2009\u00b1\u20090.65% respectively. Patients diagnosed in the late period (2020\u20132024) had lower overall mortality (7.18%\u2009\u00b1\u20091.88% vs. 14.45%\u2009\u00b1\u20092.12%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006) and TRM (0.46%\u2009\u00b1\u20090.46% vs. 3.60%\u2009\u00b1\u20091.12%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.019) rates compared with those diagnosed in the early period (2013\u20132019), primarily driven by the progress in supportive care. The outcome for patients suffering disease relapse\/refractory remained poor (18\u2010month overall mortality: 45.60%\u2009\u00b1\u200910.69% during 2020\u20132024 vs. 57.07%\u2009\u00b1\u20098.18% during 2013\u20132019,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.162). However, the growing availability of novel therapies may motivate curative salvage treatment, leading to less treatment abandonment (0.0% vs. 26.1%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.042) and lower 3\u2010month overall mortality (4.35%\u2009\u00b1\u20094.25% vs. 34.36%\u2009\u00b1\u20097.47%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007) in the late period. The increasing trend of salvage TRM in this subgroup (13.26%\u2009\u00b1\u20097.34% vs. 2.74%\u2009\u00b1\u20092.74%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.107) suggested that the survival benefits of salvage treatment may be offset by treatment toxicity. These findings indicate that children with NHL in UMICs can achieve comparable overall mortality and TRM to those in high\u2010income countries with standard treatment and appropriate supportive care.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70772","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T03:31:37Z","timestamp":1787369497000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Declining treatment\u2010related and overall mortality in children with newly diagnosed advanced\u2010stage non\u2010Hodgkin lymphoma treated in a paediatric cancer centre during 2013\u20132024, Shanghai, China"],"prefix":"10.1111","author":[{"given":"Xinyu","family":"Qiao","sequence":"first","affiliation":[{"name":"Department of Oncology, Shanghai Children's Medical Center Affiliated to School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejia","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Children's Medical Center Affiliated to School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Children's Medical Center Affiliated to School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Children's Medical Center Affiliated to School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Children's Medical Center Affiliated to School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Children's Medical Center Affiliated to School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Children's Medical Center Affiliated to School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Children's Medical Center Affiliated to School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haishan","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Children's Medical Center Affiliated to School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Children's Medical Center Affiliated to School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7592-4115","authenticated-orcid":false,"given":"Yijin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Children's Medical Center Affiliated to School of Medicine Shanghai Jiao Tong University  Shanghai 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