{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:24:27Z","timestamp":1787739867630,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>B\u2010cell maturation antigen\u2010directed chimeric antigen receptor (CAR) T cells have revolutionized the treatment of relapsed\/refractory multiple myeloma. However, no randomized head\u2010to\u2010head comparison of idecabtagene vicleucel (ide\u2010cel) and ciltacabtagene autoleucel (cilta\u2010cel) is available, and real\u2010world data suggest differences in efficacy and toxicity. We performed a nationwide retrospective real\u2010world analysis (RWA) of Austrian patients treated with ide\u2010cel or cilta\u2010cel between January 2024 and July 2025. Ninety patients were included, with largely balanced baseline characteristics and frequent high\u2010risk features. Bridging therapy was administered to 94.4% of patients, resulting in high response rates prior to lymphodepletion. After a median follow\u2010up of 17.6\u2009months, no early separation of the progression\u2010free survival (PFS) curves was observed between CAR\u2010T products. Multivariable analyses showed a trend towards improved PFS with cilta\u2010cel, whereas true extra\u2010medullary disease (EMD) and prior bispecific antibody treatment before T\u2010cell apheresis were associated with inferior PFS. Although previous RWA have demonstrated an early divergence in PFS between cilta\u2010cel and ide\u2010cel, this pattern was not observed in our cohort. The high effectiveness of bridging therapy may have contributed to these findings. Our results support further investigation of optimal bridging strategies and treatment sequencing while highlighting the persistent unmet need of patients with true EMD.<\/jats:p>","DOI":"10.1111\/bjh.70773","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:04:31Z","timestamp":1787738671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010world outcomes of ide\u2010cel and cilta\u2010cel in relapsed\/refractory multiple myeloma: A nationwide, retrospective analysis in Austria"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9649-5850","authenticated-orcid":false,"given":"Irene","family":"Strassl","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I: Hematology With Stem Cell Transplantation, Hemostaseology and Medical Oncology Ordensklinikum Linz Elisabethinen  Linz Austria"},{"name":"Medical Faculty Johannes Kepler University Linz  Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Nikoloudis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I: Hematology With Stem Cell Transplantation, Hemostaseology and Medical Oncology Ordensklinikum Linz Elisabethinen  Linz Austria"},{"name":"Medical Faculty Johannes Kepler University Linz  Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6008-029X","authenticated-orcid":false,"given":"Lina Zoe","family":"Ruesing","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Unit, Department of Medicine I Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0122-3631","authenticated-orcid":false,"given":"Thomas","family":"Melchardt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III With Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology Paracelsus Medical University Salzburg  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Leisch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III With Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology Paracelsus Medical University Salzburg  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6672-4592","authenticated-orcid":false,"given":"Eduard","family":"Schulz","sequence":"additional","affiliation":[{"name":"Clinical Division of Hematology, Department of Internal Medicine Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annkristin","family":"Heine","sequence":"additional","affiliation":[{"name":"Clinical Division of Hematology, Department of Internal Medicine Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Neumeister","sequence":"additional","affiliation":[{"name":"Clinical Division of Hematology, Department of Internal Medicine Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Normann","family":"Steiner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V, Hematology &amp; Oncology, Comprehensive Cancer Center Innsbruck (CCCI) Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V, Hematology &amp; Oncology, Comprehensive Cancer Center Innsbruck (CCCI) Medical University of Innsbruck  Innsbruck 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Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2729-9706","authenticated-orcid":false,"given":"Johannes","family":"Clausen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I: Hematology With Stem Cell Transplantation, Hemostaseology and Medical Oncology Ordensklinikum Linz Elisabethinen  Linz Austria"},{"name":"Medical Faculty Johannes Kepler University Linz  Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7369-9700","authenticated-orcid":false,"given":"Veronika","family":"Buxhofer\u2010Ausch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I: Hematology With Stem Cell Transplantation, Hemostaseology and Medical Oncology Ordensklinikum Linz Elisabethinen  Linz Austria"},{"name":"Medical Faculty Johannes Kepler University Linz  Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1247-7948","authenticated-orcid":false,"given":"Sigrid","family":"Machherndl\u2010Spandl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I: Hematology With Stem Cell Transplantation, Hemostaseology and Medical Oncology Ordensklinikum Linz Elisabethinen  Linz Austria"},{"name":"Medical Faculty Johannes Kepler University Linz  Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Saini","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I: Hematology With Stem Cell Transplantation, Hemostaseology and Medical Oncology Ordensklinikum Linz Elisabethinen  Linz Austria"},{"name":"Medical Faculty Johannes Kepler University Linz  Linz 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