{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T04:24:48Z","timestamp":1787372688801,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Preclinical and clinical studies suggest that selective serotonin reuptake inhibitors (SSRIs) can stimulate haematopoiesis by promoting proliferation and mobilization of haematopoietic stem and progenitor cells, but whether SSRI use influences myeloid malignancy risk remains unclear. We therefore conducted a nationwide case\u2013control study using Danish healthcare registries, including 22\u2009293 adults with incident myeloid malignancy diagnosed during 2001\u20132022 and 445\u2009860 cancer\u2010free controls matched 1:20 on age, sex and calendar year. Ever SSRI use was defined as \u22651 filled prescriptions, and long\u2010term use as prescriptions equivalent to &gt;3\u2009years of use. A 6\u2010month lag period was applied to minimize reverse causation. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using conditional logistic regression adjusted for comorbidities, socioeconomic status and other psychotropic medications. SSRI use was not associated with increased myeloid malignancy risk compared with never use (adjusted OR, 0.98 [95% CI, 0.94\u20131.01] for ever use; 0.92 [95% CI, 0.86\u20130.97] for long\u2010term use). No associations were observed across sex or age groups. Estimates were similar across myelodysplastic neoplasms, myeloproliferative neoplasms and acute myeloid leukaemia and individual SSRIs. These findings from a large nationwide study provide reassurance that SSRI treatment is not associated with a clinically meaningful increase in myeloid malignancy risk.<\/jats:p>","DOI":"10.1111\/bjh.70779","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T03:46:35Z","timestamp":1787370395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Use of selective serotonin reuptake inhibitors and risk of myeloid malignancy: A nationwide Danish case\u2013control study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6503-9800","authenticated-orcid":false,"given":"Katrine","family":"Mose","sequence":"first","affiliation":[{"name":"Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9314-5679","authenticated-orcid":false,"given":"Anton","family":"Potteg\u00e5rd","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1241-4385","authenticated-orcid":false,"given":"Mette","family":"Reilev","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7753-6768","authenticated-orcid":false,"given":"Christen Lykkegaard","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Hematology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Center for General Practice, Institute of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5730-9469","authenticated-orcid":false,"given":"Bl\u00e1naid","family":"Hicks","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health University of Southern Denmark  Odense Denmark"},{"name":"Centre for Public Health Queen's University Belfast  Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8528-6671","authenticated-orcid":false,"given":"Mathilde Egelund","family":"Christensen","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health University of Southern Denmark  Odense Denmark"},{"name":"Center for General Practice, Institute of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.08.005"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102004\u201001\u20100373"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20150906"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007\u20100048"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.1970.tb07016.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/stcltm\/szac055"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.02.071"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2022.11.017"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1394584"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwae087"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810393562"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw213"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394715"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015850"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001613\u20101"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811399956"},{"key":"e_1_2_11_20_1","volume-title":"ICD\u201010: international statistical classification of diseases and related health problems: tenth revision","author":"World Health Organization","year":"2004"},{"key":"e_1_2_11_21_1","volume-title":"Modern epidemiology","author":"Rothman K","year":"2008"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2023.05.004"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004457"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.47626\/2237\u20106089\u20102023\u20100680"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102009\u201003\u2010209262"},{"issue":"20","key":"e_1_2_11_26_1","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","article-title":"The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia","volume":"127","author":"Arber DA","year":"2016","journal-title":"Blood"},{"key":"e_1_2_11_26_2","doi-asserted-by":"crossref","unstructured":"Blood. 2016;128(3):462\u2013463.https:\/\/doi.org\/10.1182\/blood\u20102016\u201006\u2010721662","DOI":"10.1182\/blood-2016-06-721662"},{"key":"e_1_2_11_27_1","unstructured":"The Danish Health Data Authority.[Historical overview of cancer patient pathways] (In Danish). Accessed 15 Sep 2025. Available from:http:\/\/www.sst.dk\/da\/Fagperson\/Sygdomme\u2010lidelser\u2010og\u2010behandling\/Kraeftsygdom\/Pakkeforloeb\u2010for\u2010kraeft\/Historisk\u2010overblik"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215\u20100366(19)30414\u20106"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13020537"},{"key":"e_1_2_11_30_1","unstructured":"BarteltK ValV HiggsE FranklinB KeaneG.SSRI antidepressants associated with lower risk of blood cancers.2025. Accessed 21 Sep 2025. Available from:https:\/\/epicresearch.org\/articles\/ssri\u2010antidepressants\u2010associated\u2010with\u2010lower\u2010risk\u2010of\u2010blood\u2010cancers"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2016.10.001"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70779","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70779","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T03:46:37Z","timestamp":1787370397000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,21]]},"references-count":31,"alternative-id":["10.1111\/bjh.70779"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70779","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,21]]},"assertion":[{"value":"2026-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"bjh.70779"}}