{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:49:45Z","timestamp":1792158585774,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The cabin of an aircraft while at cruising altitude is a hypobaric hypoxic environment. The hypoxic nature of this environment may predispose sickle cell disease (SCD) passengers to vaso\u2010occlusive episodes (VOEs). Evidence on pre\u2010flight and in\u2010flight events related to SCD is limited. A retrospective analysis was undertaken of records from a ground\u2010based medical support (GBMS) provider (1.1.22\u20131.10.24) for pre\u2010flight and in\u2010flight events relating to SCD. Passenger demographics, presenting features, oxygen\/analgesia use and flight characteristics were extracted. 84 pre\u2010flight and 76 in\u2010flight SCD\u2010related cases were identified and analysed. Pre\u2010flight, 73% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200961) were cleared to fly. 33% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200928) reported current symptoms or recent symptoms (\u226410\u2009days) and 31% sought oxygen for the flight\/portable oxygen concentrator clearance. In\u2010flight, analgesia was provided in 49% (non\u2010narcotic in 37% and narcotic in 12%) of all cases. One diversion occurred (due to suspected stroke). No events were seen relating to departures from airports of high elevation. SCD\u2010related events before or during air travel were uncommon, and current measures appear to be appropriate in the prevention of diversion.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70781","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:04:51Z","timestamp":1787897091000},"page":"1838-1844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sickle cell disease and commercial aviation. A retrospective analysis of in\u2010flight and pre\u2010flight medical events"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7587-3760","authenticated-orcid":false,"given":"Karan S.","family":"Ghatora","sequence":"first","affiliation":[{"name":"The Safety &amp; Airspace Regulation Group UK Civil Aviation Authority  Crawley UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark K.","family":"Cairns","sequence":"additional","affiliation":[{"name":"The Safety &amp; Airspace Regulation Group UK Civil Aviation Authority  Crawley UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6172-4424","authenticated-orcid":false,"given":"Paulo M.","family":"Alves","sequence":"additional","affiliation":[{"name":"MedAire, Inc  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9715-9063","authenticated-orcid":false,"given":"Arne","family":"de Kreuk","sequence":"additional","affiliation":[{"name":"Department of Haematology King's College Hospital NHS Foundation Trust  London UK"},{"name":"School of Cancer &amp; Pharmaceutical Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-012418-012838"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.10233"},{"key":"e_1_2_11_4_1","volume-title":"Air travelers in America: key findings of a survey conducted by Ipsos","author":"Airlines for America (A4A)","year":"2023"},{"key":"e_1_2_11_5_1","volume-title":"How experience with international travel varies across 24 countries","author":"Wike R","year":"2023"},{"key":"e_1_2_11_6_1","unstructured":"Certification Specifications and Acceptable Means of Compliance for Large Aeroplanes (CS 25 \u2013 Amendment 27). UK Civil Aviation Authority. Available from:https:\/\/regulatorylibrary.caa.co.uk\/cs\/Content\/PDFFiles\/InitalAirworthinessAdoptedCS\u201025Amd27.pdf. Accessed 23 Dec 2025"},{"key":"e_1_2_11_7_1","unstructured":"The aircraft cabin and your health and comfort. Available from:https:\/\/www.caa.co.uk\/passengers\u2010and\u2010public\/passenger\u2010guidance\/health\u2010guidance\/guidance\u2010for\u2010health\u2010professionals\/physiology\u2010of\u2010flight\/. Accessed 23 Dec 2025"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2013.12.004"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jtm.12142"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)79607-0"},{"key":"e_1_2_11_11_1","unstructured":"Haematological disorders. Information for Health Professionals on assessing fitness to fly. Available from:https:\/\/www.caa.co.uk\/passengers\u2010and\u2010public\/before\u2010you\u2010fly\/am\u2010i\u2010fit\u2010to\u2010fly\/guidance\u2010for\u2010health\u2010professionals\/haematological\u2010disorders\/. Accessed 23 Dec 2025"},{"key":"e_1_2_11_12_1","unstructured":"Medical Considerations for Airline Travel. Anemia. Available from:https:\/\/www.asma.org\/publications\/medical\u2010publications\u2010for\u2010airline\u2010travel\/medical\u2010considerations\u2010for\u2010airline\u2010travel. Accessed 23 Dec 2025"},{"key":"e_1_2_11_13_1","unstructured":"IATA Medical Manual Edition 12. Available from:https:\/\/www.iata.org\/en\/publications\/medical\u2010manual\/. Accessed 23 Dec 2025"},{"issue":"4","key":"e_1_2_11_14_1","first-page":"403","article-title":"Medical advice for commercial air travel","volume":"104","author":"Powell\u2010Dunford N","year":"2021","journal-title":"Am Fam Physician"},{"key":"e_1_2_11_15_1","volume-title":"IATA by region","author":"International Air Transport Association","year":"2025"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00118-7"},{"key":"e_1_2_11_17_1","unstructured":"AMC1 CAT.IDE.A.225 Emergency medical kit. Available from:https:\/\/regulatorylibrary.caa.co.uk\/air\u2010operations\u2010pre\u201030\u2010october\u20102025\/Content\/Document%20Structure\/04%20CAT\/3%20AMC\/AMC1%20CAT%20IDE%20A%20225%20Emergency.htm. Accessed 9 July 2026"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07354.x"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70781","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70781","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:10:06Z","timestamp":1792156206000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/bjh.70781"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70781","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]},"assertion":[{"value":"2026-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}