{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:27:08Z","timestamp":1788535628645,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The randomized phase II SAKK 35\/14 trial, conducted by the Swiss Group for Clinical Cancer Research (SAKK) and the Nordic Lymphoma Group (NLG), compared efficacy and safety of rituximab (375\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    intravenously for 4\u2009weeks followed by maintenance every 2 months for 24\u2009months) plus placebo (arm A) versus the same schedule of rituximab plus ibrutinib (560\u2009mg daily for 24\u2009months, arm B) in patients with advanced follicular lymphoma in need of systemic therapy. The primary end\u2010point, complete remission (CR) rate at 24\u2009months, was 36% in arm A and 40% in arm B, with no statistically significant difference. Three\u2010year progression\u2010free survival (PFS) was 36% in arm A and 45% in arm B, with a hazard ratio of 0.64 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.057). Three\u2010year overall survival was about 96% in both arms. A higher percentage of patients in arm B experienced grade \u22653 adverse events, but they were manageable. No toxic deaths were observed. Although the primary end\u2010point (CR rate at 24\u2009months) was not met, a trend towards improved PFS with ibrutinib plus rituximab observed at the prespecified significance level of 0.1 may indicate a potential clinical benefit.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70801","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:25:13Z","timestamp":1788150313000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>SAKK<\/scp>\n                    35\/14 randomized trial of rituximab with or without ibrutinib for patients with untreated follicular lymphoma"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5277-9835","authenticated-orcid":false,"given":"Maria Cristina","family":"Pirosa","sequence":"first","affiliation":[{"name":"Institute of Oncology Research  Bellinzona Switzerland"},{"name":"Oncology Institute of Southern Switzerland Ente 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