{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T09:16:42Z","timestamp":1788167802246,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>While marginal zone lymphoma (MZL) is generally indolent, outcomes following relapse remain poorly defined. This study utilized the indolent Non Follicular 10 (NF10) prospective database to characterize survival and identify prognostic drivers in patients failing initial systemic therapy. The study analysed 122 patients with relapsed MZL. The primary end\u2010point was progression\u2010free survival from first relapse (2PFS), with survival after relapse (SAR) as the secondary end\u2010point. The median 2PFS was 24\u2009months, with a 2\u2010year 2PFS rate of 49% and a 2\u2010year SAR rate of 66%. Multivariable analysis identified advanced age, progression of disease within 24\u2009months (POD24) and high MZL International Prognostic Index (MZL\u2010IPI) scores as significant predictors of inferior survival. Patients with splenic and disseminated subtypes also demonstrated worse outcomes. Relapse following systemic therapy often marks a transition to an aggressive clinical course. Time to progression and the MZL\u2010IPI are robust tools for risk stratification, highlighting an urgent need for novel therapeutic strategies for high\u2010risk relapsed MZL populations.<\/jats:p>","DOI":"10.1111\/bjh.70808","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:31:26Z","timestamp":1788150686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Survival after first relapse in marginal zone lymphomas: Prospective data from the international observational\n                    <scp>NF10<\/scp>\n                    study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8446-2285","authenticated-orcid":false,"given":"Stefano","family":"Luminari","sequence":"first","affiliation":[{"name":"Division of Hematology Azienda Unit\u00e0 Sanitaria Locale IRCCS of Reggio Emilia  Reggio Emilia Italy"},{"name":"CHIMOMO Department University of Modena and Reggio Emilia  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elena","family":"Nizzoli","sequence":"additional","affiliation":[{"name":"Division of Hematology Azienda Unit\u00e0 Sanitaria Locale IRCCS of Reggio Emilia  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0905-5927","authenticated-orcid":false,"given":"Michele","family":"Merli","sequence":"additional","affiliation":[{"name":"Division of Hematology Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2682-3414","authenticated-orcid":false,"given":"Sara","family":"Rattotti","sequence":"additional","affiliation":[{"name":"Division of Hematology Fondazione IRCCS Policlinico San Matteo and University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3205-0566","authenticated-orcid":false,"given":"Vittoria","family":"Tarantino","sequence":"additional","affiliation":[{"name":"Division of Hematology Azienda Ospedaliera Ospedali Riuniti Villa Sofia\u2010Cervello  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9711-1502","authenticated-orcid":false,"given":"Simone","family":"Ferrero","sequence":"additional","affiliation":[{"name":"Hematology Division, Department of Molecular Biotechnology and Health Sciences University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7604-2598","authenticated-orcid":false,"given":"Annalisa","family":"Talami","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Medicine Doctorate School Universit\u00e0 Degli Studi di Modena e Reggio Emilia  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9792-9542","authenticated-orcid":false,"given":"Roberta","family":"Murru","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplantation Unit Ospedale Oncologico A. Businco, ARNAS G. Brotzu  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0010-6107","authenticated-orcid":false,"given":"Marina","family":"Deodato","sequence":"additional","affiliation":[{"name":"Department of Hematology Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0432-9706","authenticated-orcid":false,"given":"Emanuele","family":"Cencini","sequence":"additional","affiliation":[{"name":"Division of Hematology Azienda Ospedaliera Universitaria Senese &amp; University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8664-950X","authenticated-orcid":false,"given":"Giovanni","family":"Roti","sequence":"additional","affiliation":[{"name":"Division of Hematology Azienda Ospedaliera Universitaria di Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Visco","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplant Unit, Department of Engineering for Innovative Medicine University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6058-7558","authenticated-orcid":false,"given":"Guilherme","family":"Duffles","sequence":"additional","affiliation":[{"name":"Hematology and Hemotherapy Centre, University of Campinas  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6576-8182","authenticated-orcid":false,"given":"Michele","family":"Spina","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology IRCCS Centro Di Riferimento Oncologico  Aviano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ombretta","family":"Annibali","sequence":"additional","affiliation":[{"name":"Division of Hematology, Stem Cell Transplantation Fondazione Policlinico Universitario Campus Bio Medico  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7429-8004","authenticated-orcid":false,"given":"Alessandro","family":"Pulsoni","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Translational and Precision Medicine, S.M. Goretti Hospital Sapienza University\u2014Polo Pontino  Latina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9606-6124","authenticated-orcid":false,"given":"Andr\u00e9s Jos\u00e9 Mar\u00eda","family":"Ferreri","sequence":"additional","affiliation":[{"name":"Strategic Program on Lymphomas IRCCS San Raffaele Scientific Institute, Milano and Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Stelitano","sequence":"additional","affiliation":[{"name":"Division of Hematology Grande Ospedale Metropolitano, Bianchi Melacrino Morelli  Reggio Calabria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8041-6424","authenticated-orcid":false,"given":"Elsa","family":"Pennese","sequence":"additional","affiliation":[{"name":"Centro Diagnosi e Terapia Dei Linfomi, Presidio Ospedaliero Spirito Santo  Pescara 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