{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:49:35Z","timestamp":1792158575670,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"Summary<\/jats:title>\n \n In patients with sickle cell disease (SCD), parvovirus B19 infection (B19V) leads to acute anaemia (aplastic crisis), but may also be associated with other serious complications. We retrospectively analysed clinical data from paediatric SCD patients with B19V infections between 2023 and 2025, including symptoms, laboratory parameters, diagnostic procedures and treatment details to detect differences between SCD genotypes (HbSS and HbS\/\u03b2\n 0<\/jats:sup>\n \u2010thalassaemia, i.e. HbSS\/S\u03b2\n 0<\/jats:sup>\n , and HbSC) and to determine the effect of hydroxyurea (HU; hydroxycarbamide) treatment in HbSS\/S\u03b2\n 0<\/jats:sup>\n patients. Ninety\u2010eight patients (76 HbSS\/S\u03b2\n 0<\/jats:sup>\n , 22 HbSC) were included in the study. There were significant differences in the symptoms of infection between genotypes, with a high prevalence of back pain as well as higher C\u2010reactive protein and lactate dehydrogenase levels in HbSC. HbSC patients also received chest X\u2010ray more frequently and required longer inpatient treatment. In addition, HbSC patients showed a significantly higher rate of immunoglobulin G seroconversion at the onset of symptoms, suggesting that antibody formation influences clinical appearance. In HbSS\/S\u03b2\n 0<\/jats:sup>\n patients, HU treatment was associated with higher haemoglobin and reduced transfusion requirements, but more frequently with neutropenia. In summary, B19V infections induce different clinical presentations depending on SCD genotypes, with HbSC patients showing a distinct phenotypic presentation. HU treatment reduces the need for transfusions in patients with HbSS\/S\u03b2\n 0<\/jats:sup>\n .\n <\/jats:p>","DOI":"10.1111\/bjh.70809","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T02:04:47Z","timestamp":1789351487000},"page":"1845-1855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Parvovirus\n B19<\/scp>\n infections in paediatric sickle cell disease patients: Genotype and hydroxyurea treatment influence disease severity"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0455-8338","authenticated-orcid":false,"given":"Matthias","family":"Bleeke","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9558-3330","authenticated-orcid":false,"given":"Arne","family":"Simon","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Saarland University Hospital and Saarland University Faculty of Medicine Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4050-9819","authenticated-orcid":false,"given":"Beate","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4856-7016","authenticated-orcid":false,"given":"Sabine","family":"Heine","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Saarland University Hospital and Saarland University Faculty of Medicine Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2256-6633","authenticated-orcid":false,"given":"Anna","family":"Eichinger","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dr. von Hauner Children's Hospital University Hospital LMU Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"von Both","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dr. von Hauner Children's Hospital University Hospital LMU Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3082-0132","authenticated-orcid":false,"given":"Meinolf","family":"Siepermann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Children's Hospital Amsterdamer Stra\u00dfe Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5820-7298","authenticated-orcid":false,"given":"Sonya","family":"El Amouri","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6121-4737","authenticated-orcid":false,"given":"Arndt","family":"Borkhardt","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Pritschow","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Ulm University Medical Center Ulm Germany"},{"name":"Center for Rare Hematopoietic Disorders and Immunodeficiencies Ulm University Medical Center Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9014-5658","authenticated-orcid":false,"given":"Wolfgang","family":"Novak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine St. Anna Children's Hospital, Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8175-1097","authenticated-orcid":false,"given":"Michael","family":"Dworzak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine St. Anna Children's Hospital, Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5218-070X","authenticated-orcid":false,"given":"Sarah","family":"Goretzki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology University of Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Held","sequence":"additional","affiliation":[{"name":"Department of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology University of Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Beutel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, TUM School of Medicine and Health Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Gams","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, TUM School of Medicine and Health Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3809-4861","authenticated-orcid":false,"given":"Henriette","family":"Rudolph","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Goethe\u2010University Frankfurt Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Koscher","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Goethe\u2010University Frankfurt Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2656-6762","authenticated-orcid":false,"given":"Piet E.","family":"Beusker","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Medical School and University Medical Center OWL, Protestant Hospital of the Bethel Foundation Bielefeld University Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2996-8248","authenticated-orcid":false,"given":"Eckard","family":"Hamelmann","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Medical School and University Medical Center OWL, Protestant Hospital of the Bethel Foundation Bielefeld University Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Weichert","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology University of Mannheim Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja","family":"H\u00e4user","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology University of Mannheim Mannheim 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regine","family":"Grosse","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Gemeinschaftsklinikum Mittelrhein Koblenz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0081-4070","authenticated-orcid":false,"given":"Rainer","family":"Misgeld","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Gemeinschaftsklinikum Mittelrhein Koblenz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3277-7212","authenticated-orcid":false,"given":"Martina","family":"Stiefel","sequence":"additional","affiliation":[{"name":"University Hospital Halle (Saale), Department of Pediatrics I Martin Luther University Halle\u2010Wittenberg Halle 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