{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T08:12:25Z","timestamp":1789805545007,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470166"],"award-info":[{"award-number":["82470166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Hyperdiploidy (HRD) is the most common genetic subtype in multiple myeloma (MM) but with significant prognostic heterogeneity. In this integrated Single Nucleotide Polymorphism (SNP\u2010array) and Fluorescence In\u00a0Situ Hybridization (FISH) analysis of 694 newly diagnosed Chinese MM patients, a modal chromosome count &gt;49 predicted superior overall survival (OS,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0062) and progression\u2010free survival (PFS,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.00037), outperforming other metrics. Gain of chromosome 3 was favourable for OS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0024) and PFS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.00078). Notably, HRD improved OS in patients with isolated 1q21\n                    <jats:sup>+<\/jats:sup>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.011) but not in those harbouring high\u2010risk abnormalities (t(4;14), t(14;16), 17p\n                    <jats:sup>\u2212<\/jats:sup>\n                    or 1p32\n                    <jats:sup>\u2212<\/jats:sup>\n                    ). The prognostic value of modal count was cytogenetic abnormality (CA)\u2010dependent: in HRD without high\u2010risk CAs, &gt;49 conferred better OS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01) and PFS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001); in isolated 1q21\n                    <jats:sup>+<\/jats:sup>\n                    , a favourable trend was observed; but no discrimination in other high\u2010risk CAs. Autologous haematopoietic stem cell transplantation (AHSCT) significantly improved OS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014) and showed a PFS trend (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.062) only in HRD patients without high\u2010risk CAs and with &gt;49 chromosomes. In conclusion, modal chromosome count &gt;49 and chromosome 3 gain are robust favourable markers in HRD. HRD provides survival benefit in isolated 1q21\n                    <jats:sup>+<\/jats:sup>\n                    . FISH\u2010based detection of trisomy 3 may offer a rapid, economical alternative for risk assessment of HRD. AHSCT benefit is restricted to low\u2010risk HRD with higher ploidy.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70817","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:36:36Z","timestamp":1789803396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyperdiploid multiple myeloma: A heterogeneous entity requiring refined risk stratification\u2014Insights from chromosome count and cytogenetic abnormalities"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8529-9782","authenticated-orcid":false,"given":"Zhao","family":"Zeng","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology Soochow University  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