{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:12:20Z","timestamp":1788858740875,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Estimated pulse wave velocity (ePWV), a simple surrogate of arterial stiffness, predicts cardiovascular events in general and oncology populations, but its relevance in myeloproliferative neoplasms (MPN) is unknown. We evaluated the association of baseline ePWV with major adverse cardiovascular events (MACE) and overall survival (OS) in 664 patients with essential thrombocythaemia (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009477) or polycythaemia vera (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009187). Median ePWV was 11.1\u2009m\/s (interquartile range [IQR], 9.2\u201312.9), and 72.1% met criteria for early vascular ageing (\u22659.4\u2009m\/s). Over a median follow\u2010up of 67.4\u2009months, 58 first MACE (8.7%) and 58 deaths (8.7%) occurred. In multivariable cause\u2010specific Cox models, each 1\u2009m\/s higher baseline ePWV was independently associated with MACE (hazard ratio [HR] 1.16, 95% confidence interval [CI] 1.02\u20131.32;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.025). The adjusted HRs were 1.18 (95% CI 1.00\u20131.39;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.054) for arterial thrombosis and 0.98 (95% CI 0.74\u20131.28;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.860) for venous thromboembolism. For OS, ePWV lost significance after adjustment for age (HR 0.92,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.670). Among\n                    <jats:italic>JAK2<\/jats:italic>\n                    \u2010mutated patients,\n                    <jats:italic>JAK2<\/jats:italic>\n                    V617F variant allele fraction showed a significant correlation with ePWV (\n                    <jats:italic>\u03c1<\/jats:italic>\n                    \u2009=\u20090.134;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.022). These findings identify ePWV as a scalable marker of vascular ageing associated with cardiovascular risk in MPN, warranting prospective validation.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70820","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:58:34Z","timestamp":1788857914000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Estimated pulse wave velocity as a marker of major adverse cardiovascular events in essential thrombocythaemia and polycythaemia vera"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7726-2936","authenticated-orcid":false,"given":"Alessandro","family":"Costa","sequence":"first","affiliation":[{"name":"Hematology and BMT Unit, \u201cA. Businco\u201d Hospital, ARNAS Brotzu  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7487-3328","authenticated-orcid":false,"given":"Olga","family":"Mulas","sequence":"additional","affiliation":[{"name":"Hematology and BMT Unit, \u201cA. Businco\u201d Hospital, ARNAS Brotzu  Cagliari Italy"},{"name":"Hematology Unit, Businco Hospital, Department of Medical Sciences and Public Health University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Pilo","sequence":"additional","affiliation":[{"name":"Hematology and BMT Unit, \u201cA. Businco\u201d Hospital, ARNAS Brotzu  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2350-9980","authenticated-orcid":false,"given":"Eleonora","family":"Atzeni","sequence":"additional","affiliation":[{"name":"Hematology Unit, Businco Hospital, Department of Medical Sciences and Public Health University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Pettinau","sequence":"additional","affiliation":[{"name":"Hematology and BMT Unit, \u201cA. Businco\u201d Hospital, ARNAS Brotzu  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Mantovani","sequence":"additional","affiliation":[{"name":"Hematology and BMT Unit, \u201cA. Businco\u201d Hospital, ARNAS Brotzu  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6585-5187","authenticated-orcid":false,"given":"Giovanni","family":"Caocci","sequence":"additional","affiliation":[{"name":"Hematology and BMT Unit, \u201cA. Businco\u201d Hospital, ARNAS Brotzu  Cagliari Italy"},{"name":"Hematology Unit, Businco Hospital, Department of Medical Sciences and Public Health University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1406186"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010021\u201001170\u2010z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bvth.2025.100051"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.25349"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010025\u201002346\u20100"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.09.063"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000033"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000935"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000453073"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201007198\u2010w"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.125.041645"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13226811"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001613\u20101"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2015.94"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.14088"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1716614"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889\u2010024\u201018071\u20102"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2022.04.002"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI124566"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI155724"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001404"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI180066"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102013\u201011\u2010539098"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2020.01.001"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010021\u201000581\u20106"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70820","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70820","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70820","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:58:35Z","timestamp":1788857915000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":26,"alternative-id":["10.1111\/bjh.70820"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70820","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]},"assertion":[{"value":"2026-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"bjh.70820"}}