{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:07:32Z","timestamp":1789027652796,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["18ek0510023h0002"],"award-info":[{"award-number":["18ek0510023h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Unrelated cord blood transplantation (CBT) is an important alternative donor option for adult patients with myelodysplastic syndrome (MDS); however, the prognostic significance of cord blood unit characteristics following CBT remains unclear and may vary according to disease risk. We conducted a nationwide retrospective study of 1767 adult patients with MDS who underwent first single\u2010unit CBT between 1999 and 2023, including 529 patients with low\u2010risk and 1238 with high\u2010risk disease at transplantation. Cord blood unit characteristics were not significantly associated with disease\u2010free survival (DFS) in patients with low\u2010risk MDS. In contrast, in patients with high\u2010risk MDS, higher cryopreserved cluster of differentiation (CD)34\n                    <jats:sup>+<\/jats:sup>\n                    cell dose and higher colony\u2010forming unit\u2013granulocyte\/macrophage dose were associated with improved DFS, whereas human leucocyte antigen (HLA) serological one\u2010locus mismatch and female\u2010to\u2010male donor\u2013recipient sex mismatch were independently associated with inferior DFS. Restricted cubic spline Cox regression demonstrated a significant non\u2010linear association between CD34\n                    <jats:sup>+<\/jats:sup>\n                    cell dose and DFS, as well as relapse, in high\u2010risk MDS. These findings demonstrate that the prognostic impact of cord blood unit characteristics after single\u2010unit CBT differs according to MDS risk status and support a risk\u2010adapted approach to cord blood unit selection, particularly for patients with high\u2010risk MDS.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70822","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:31:34Z","timestamp":1789025494000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimizing cord blood unit selection to improve survival after single\u2010unit unrelated cord blood transplantation for adult myelodysplastic syndrome"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1953-8463","authenticated-orcid":false,"given":"Takaaki","family":"Konuma","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology, The Institute of Medical Science The 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