{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:16:51Z","timestamp":1788412611363,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515012632"],"award-info":[{"award-number":["2025A1515012632"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Bispecific antibodies (BsAbs) targeting B\u2010cell maturation antigen (BCMA) or G protein\u2010coupled receptor, class C, group 5, member D (GPRC5D) represent effective options for relapsed or refractory multiple myeloma (RRMM), yet direct comparative evidence remains limited. We performed a systematic review and meta\u2010analysis of studies evaluating BCMA\u2010 or GPRC5D\u2010targeted BsAbs in RRMM. Thirty studies comprising 3218 patients were included. Random\u2010effects models were used to pool efficacy and safety outcomes, followed by meta\u2010regression to identify study\u2010level moderators of response. At the recommended phase 2 dose, BCMA\u2010 and GPRC5D\u2010targeted BsAbs showed comparable efficacy, with overall response rates (ORRs) of 65% (95% confidence interval [CI], 60%\u201370%) and 70% (95% CI, 66%\u201373%) respectively. Rates of \u2265very good partial response and complete response were also similar. Any\u2010grade cytokine release syndrome (CRS) was more frequent with GPRC5D BsAbs (57% vs. 74%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006), whereas grade \u22653 CRS and other severe toxicities, including neurotoxicity, infections and haematological adverse events (AEs), were broadly comparable. Meta\u2010regression identified prior penta\u2010drug exposure and higher median lines of therapy as negative moderators of response, with prior BCMA\u2010directed therapy further associated with reduced efficacy in BCMA\u2010targeted cohorts. Overall, BCMA\u2010 and GPRC5D\u2010targeted BsAbs demonstrated comparable efficacy. Among the commonly reported non\u2010target specific AEs, the safety profile was broadly comparable. The response appeared to be influenced primarily by treatment history.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70824","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:40:55Z","timestamp":1788410455000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>BCMA<\/scp>\n                    versus\n                    <scp>GPRC5D<\/scp>\n                    bispecific antibodies in relapsed\/refractory multiple myeloma: A systematic review and meta\u2010analysis guiding treatment selection"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5584-2263","authenticated-orcid":false,"given":"Qi","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Hematologic Oncology Sun Yat\u2010Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shutong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology Sun Yat\u2010Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology Sun Yat\u2010Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology Sun Yat\u2010Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine  Guangzhou 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Sun Yat\u2010Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology Sun Yat\u2010Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4226-9580","authenticated-orcid":false,"given":"Yang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology Sun Yat\u2010Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5836-0872","authenticated-orcid":false,"given":"Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology Sun Yat\u2010Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine  Guangzhou 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