{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T02:03:33Z","timestamp":1789351413537,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006566","name":"National Plan for Science,Technology and Innovation","doi-asserted-by":"publisher","award":["13\u2010MED1375\u201002"],"award-info":[{"award-number":["13\u2010MED1375\u201002"]}],"id":[{"id":"10.13039\/501100006566","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Stroke is a major cause of morbidity in sickle cell disease (SCD); however, contemporary longitudinal data from Saudi cohorts remain limited. We examined stroke incidence, phenotype and laboratory correlates in 195 patients with homozygous sickle cell anaemia (HbSS) or sickle \u03b2\u2070\u2010thalassaemia (HbS\/\u03b2\u2070), predominantly from southwestern regions (median age at enrolment, 16.5\u2009years; 53% male; median baseline haemoglobin, 8.9\u2009g\/dL; fetal haemoglobin [HbF], 10.5%), followed for a median of 13.5\u2009years (2009\u20132025; 2173 patient\u2010years). Hydroxyurea (hydroxycarbamide) use increased from 44% at enrolment to 85% at follow\u2010up. Fourteen strokes (13 ischaemic, 1 haemorrhagic) occurred at a median age of 28\u2009years, an overall incidence of 0.64 per 100 patient\u2010years (0.39 in &lt;18\u2009years to 0.93 in &gt;30\u2009years), with no overt stroke before age 10. By age 30, cumulative incidence of overt ischaemic stroke and silent cerebral infarcts (SCIs) reached 5.0% and 18.6% respectively. In age\u2010 and sex\u2010adjusted models, higher baseline lactate dehydrogenase (LDH) was associated with ischaemic stroke (incidence rate ratio [IRR], 1.46 per 100\u2009U\/L; 95% confidence interval [CI], 1.11\u20131.91;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007); HbF showed a protective trend (IRR 0.55 per 5% increase; 95% CI, 0.29\u20131.06;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.07). This age\u2010related stroke pattern without a childhood peak may reflect higher baseline HbF, expanded hydroxyurea use, and supportive care improvements, although population\u2010specific modifiers cannot be excluded.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70830","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:41:37Z","timestamp":1789350097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stroke incidence and phenotype in Saudi patients with sickle cell disease: A longitudinal cohort study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8231-5005","authenticated-orcid":false,"given":"Mohammed","family":"Al\u2010Agha","sequence":"first","affiliation":[{"name":"Oncology Center King Saud University Medical City  Riyadh Saudi Arabia"},{"name":"Department of Pediatrics, College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1988-0442","authenticated-orcid":false,"given":"Fahad","family":"Albadr","sequence":"additional","affiliation":[{"name":"Department of Radiology, College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5774-0358","authenticated-orcid":false,"given":"Aamer","family":"Aleem","sequence":"additional","affiliation":[{"name":"Oncology Center King Saud University Medical City  Riyadh Saudi Arabia"},{"name":"Department of Internal Medicine, College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6552-6260","authenticated-orcid":false,"given":"Farjah H.","family":"Algahtani","sequence":"additional","affiliation":[{"name":"Oncology Center King Saud University Medical City  Riyadh Saudi Arabia"},{"name":"Department of Internal Medicine, College of Medicine King Saud University  Riyadh Saudi Arabia"},{"name":"Chair of Epidemiology and Public Health Research King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Al\u2010Shehri","sequence":"additional","affiliation":[{"name":"Oncology Center King Saud University Medical City  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1436-6727","authenticated-orcid":false,"given":"Fahad","family":"Bashiri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5577-3228","authenticated-orcid":false,"given":"Abdulrahman","family":"Alsultan","sequence":"additional","affiliation":[{"name":"Oncology Center King Saud University Medical City  Riyadh Saudi Arabia"},{"name":"Department of Pediatrics, College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,13]]},"reference":[{"issue":"1","key":"e_1_2_12_2_1","first-page":"288","article-title":"Cerebrovascular accidents in sickle cell disease: rates and risk factors","volume":"91","author":"Ohene\u2010Frempong K","year":"1998","journal-title":"Blood"},{"issue":"6","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/01.md.0000189089.45003.52","article-title":"Outcome of sickle cell anemia: a 4\u2010decade observational study of 1056 patients","volume":"84","author":"Powars DR","year":"2005","journal-title":"Medicine (Baltimore)"},{"issue":"2","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/MPH.0b013e3182422844","article-title":"Sickle cell disease subphenotypes in patients from Southwestern Province of Saudi Arabia","volume":"34","author":"Alsultan A","year":"2012","journal-title":"J Pediatr Hematol Oncol"},{"issue":"4","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/bjh.12650","article-title":"Sickle cell disease in Saudi Arabia: the phenotype in adults with the Arab\u2010Indian haplotype is not benign","volume":"164","author":"Alsultan A","year":"2014","journal-title":"Br J Haematol"},{"issue":"5","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"472","DOI":"10.5144\/0256-4947.1998.472","article-title":"Stroke among sickle cell disease patients in Madina maternity and Children's hospital","volume":"18","author":"Al Hawsawi ZM","year":"1998","journal-title":"Ann Saudi Med"},{"issue":"1","key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1186\/s12916-020-01864-8","article-title":"Silent cerebral infarcts in patients with sickle cell disease: a systematic review and meta\u2010analysis","volume":"18","author":"Houwing ME","year":"2020","journal-title":"BMC Med"},{"issue":"18","key":"e_1_2_12_8_1","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10184232","article-title":"Epidemiology of stroke in sickle cell disease","volume":"10","author":"Kirkham FJ","year":"2021","journal-title":"J Clin Med"},{"issue":"7","key":"e_1_2_12_9_1","article-title":"Prevalence and risk factors of stroke among children with sickle cell disease: a retrospective study at a tertiary care center","volume":"15","author":"Babeer G","year":"2023","journal-title":"Cureus"},{"issue":"4","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1182\/blood-2010-12-326298","article-title":"Discontinuing prophylactic transfusions increases the risk of silent brain infarction in children with sickle cell disease: data from STOP II","volume":"118","author":"Abboud MR","year":"2011","journal-title":"Blood"},{"issue":"17","key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1182\/blood-2011-11-392340","article-title":"Stroke with transfusions changing to Hydroxyurea (SWiTCH)","volume":"119","author":"Ware RE","year":"2012","journal-title":"Blood"},{"issue":"10019","key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0140-6736(15)01041-7","article-title":"Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia\u2010TCD with transfusions changing to Hydroxyurea (TWiTCH): a multicentre, open\u2010label, phase 3, non\u2010inferiority trial","volume":"387","author":"Ware RE","year":"2016","journal-title":"Lancet"},{"issue":"8","key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJMoa1401731","article-title":"Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia","volume":"371","author":"DeBaun MR","year":"2014","journal-title":"N Engl J Med"},{"issue":"3","key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1172\/JCI89741","article-title":"Intravascular hemolysis and the pathophysiology of sickle cell disease","volume":"127","author":"Kato GJ","year":"2017","journal-title":"J Clin Invest"},{"issue":"10","key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"4314","DOI":"10.1182\/blood-2008-03-143891","article-title":"G6PD deficiency, absence of alpha\u2010thalassemia, and hemolytic rate at baseline are significant independent risk factors for abnormally high cerebral velocities in patients with sickle cell anemia","volume":"112","author":"Bernaudin F","year":"2008","journal-title":"Blood"},{"key":"e_1_2_12_16_1","unstructured":"SteinbergMH.Pathophysiology of sickle cell disease: UpToDate Inc. [updated 2026\u201001\u201005]. Available from:https:\/\/www.uptodate.com\/contents\/pathophysiology\u2010of\u2010sickle\u2010cell\u2010disease"},{"issue":"5","key":"e_1_2_12_17_1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/pbc.24392","article-title":"National trends in incidence rates of hospitalization for stroke in children with sickle cell disease","volume":"60","author":"McCavit TL","year":"2013","journal-title":"Pediatr Blood Cancer"},{"issue":"9","key":"e_1_2_12_18_1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/ajh.21476","article-title":"The excess burden of stroke in hospitalized adults with sickle cell disease","volume":"84","author":"Strouse JJ","year":"2009","journal-title":"Am J Hematol"},{"issue":"1","key":"e_1_2_12_19_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1080\/03630269.2025.2462174","article-title":"Long\u2010term survival rates of a sickle cell disease cohort in Saudi Arabia: a 2009\u20102023 observational study","volume":"49","author":"Aloofy TA","year":"2025","journal-title":"Hemoglobin"},{"issue":"9778","key":"e_1_2_12_20_1","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/S0140-6736(11)60355-3","article-title":"Hydroxycarbamide in very young children with sickle\u2010cell anaemia: a multicentre, randomised, controlled trial (BABY HUG)","volume":"377","author":"Wang WC","year":"2011","journal-title":"Lancet"},{"issue":"2","key":"e_1_2_12_21_1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1161\/STROKEAHA.111.624585","article-title":"Towards a consensus\u2010based classification of childhood arterial ischemic stroke","volume":"43","author":"Bernard TJ","year":"2012","journal-title":"Stroke"},{"issue":"7","key":"e_1_2_12_22_1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2176\/jns-nmc.2022-0072","article-title":"Diagnostic criteria for Moyamoya disease \u2010 2021 revised version","volume":"62","author":"Kuroda S","year":"2022","journal-title":"Neurol Med Chir (Tokyo)"},{"issue":"1","key":"e_1_2_12_23_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11222-019-09860-6","article-title":"Mean and median bias reduction in generalized linear models","volume":"30","author":"Kosmidis I","year":"2020","journal-title":"Stat Comput"},{"issue":"24","key":"e_1_2_12_24_1","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1182\/blood.2023023031","article-title":"Rates of strokes in Californians with sickle cell disease in the post\u2010STOP era","volume":"144","author":"Oluwole O","year":"2024","journal-title":"Blood"},{"issue":"4","key":"e_1_2_12_25_1","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1182\/blood-2010-06-293514","article-title":"Impact of early transcranial Doppler screening and intensive therapy on cerebral vasculopathy outcome in a newborn sickle cell anemia cohort","volume":"117","author":"Bernaudin F","year":"2011","journal-title":"Blood"},{"issue":"12","key":"e_1_2_12_26_1","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1002\/ajh.25635","article-title":"Ischemic stroke in children and young adults with sickle cell disease in the post\u2010STOP era","volume":"94","author":"Kwiatkowski JL","year":"2019","journal-title":"Am J Hematol"},{"issue":"11","key":"e_1_2_12_27_1","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1182\/blood.V108.11.1200.1200","article-title":"Collaborative data project [C\u2010DATA] of the comprehensive sickle cell centers program","volume":"108","author":"Rogers ZR","year":"2006","journal-title":"Blood"},{"issue":"11","key":"e_1_2_12_28_1","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1182\/blood-2003-11-3758","article-title":"Survival of children with sickle cell disease","volume":"103","author":"Quinn CT","year":"2004","journal-title":"Blood"},{"issue":"4","key":"e_1_2_12_29_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.21089\/njhs.94.0235","article-title":"Frequency of stroke among children with sickle cell disease in southern region of Saudi Arabia: single center experience","volume":"9","author":"Al Asmari BG","year":"2024","journal-title":"Natl J Health Sci"},{"issue":"11","key":"e_1_2_12_30_1","article-title":"Moyamoya syndrome in children with sickle cell disease in Saudi Arabia: a single\u2010center experience","volume":"15","author":"Zayed AM","year":"2023","journal-title":"Cureus"},{"issue":"2","key":"e_1_2_12_31_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/02724936.1990.11747429","article-title":"Cerebrovascular accidents (strokes) in children with sickle cell disease residing at high and low altitudes of Saudi Arabia","volume":"10","author":"Annobil SH","year":"1990","journal-title":"Ann Trop Paediatr"},{"issue":"6","key":"e_1_2_12_32_1","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/bjh.13916","article-title":"Clinical and haematological risk factors for cerebral macrovasculopathy in a sickle cell disease newborn cohort: a prospective study","volume":"172","author":"Sommet J","year":"2016","journal-title":"Br J Haematol"},{"key":"e_1_2_12_33_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0002-9343(78)90772-6","article-title":"The natural history of stroke in sickle cell disease","volume":"65","author":"Powars D","year":"1978","journal-title":"Am J Med"},{"issue":"11","key":"e_1_2_12_34_1","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V112.11.2497.2497","article-title":"Cerebral vasculopathy outcome in a sickle cell anemia (SCA) newborn cohort screened early with transcranial Doppler","volume":"112","author":"Bernaudin F","year":"2008","journal-title":"Blood"},{"issue":"1","key":"e_1_2_12_35_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bglo.2025.100001","article-title":"Hydroxyurea to decrease stroke risk in children with sickle cell anemia: a systematic review and meta\u2010analysis","volume":"1","author":"Ambrose EE","year":"2025","journal-title":"Blood Glob Hematol"},{"issue":"8","key":"e_1_2_12_36_1","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1182\/blood.V99.8.3014","article-title":"Longitudinal changes in brain magnetic resonance imaging findings in children with sickle cell disease","volume":"99","author":"Pegelow CH","year":"2002","journal-title":"Blood"},{"issue":"4","key":"e_1_2_12_37_1","first-page":"E117","article-title":"Sickle cell disease in the Eastern Province of Saudi Arabia: clinical and laboratory features","volume":"96","author":"Al\u2010Ali AK","year":"2021","journal-title":"Am J Hematol"},{"key":"e_1_2_12_38_1","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1177\/15353702211035778","article-title":"Progression of central nervous system disease from pediatric to young adulthood in sickle cell anemia","volume":"246","author":"Champlin G","year":"2021","journal-title":"Exp Biol Med (Maywood)"},{"key":"e_1_2_12_39_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/bjh.14235","article-title":"Hydroxycarbamide treatment and brain MRI\/MRA findings in children with sickle cell anaemia","volume":"175","author":"Nottage K","year":"2016","journal-title":"Br J Haematol"},{"key":"e_1_2_12_40_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pediatrneurol.2019.12.008","article-title":"Cerebral infarcts and vasculopathy in Tanzanian children with sickle cell anemia","volume":"107","author":"Jacob M","year":"2020","journal-title":"Pediatr Neurol"},{"issue":"1","key":"e_1_2_12_41_1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1182\/blood-2025-617","article-title":"Prospective hydroxyurea impact on cerebral magnetic resonance imaging from a 30\u2010month trial of children with sickle cell anemia in Uganda","volume":"146","author":"Idro R","year":"2025","journal-title":"Blood"},{"issue":"11","key":"e_1_2_12_42_1","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V110.11.430.430","article-title":"High LDH level, G6PD deficiency and absence of alpha\u2010thalassemia are significant independent risk factors of abnormally high cerebral velocities in patients with sickle cell anemia","volume":"110","author":"Bernaudin F","year":"2007","journal-title":"Blood"},{"key":"e_1_2_12_43_1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1055\/s-0045-1811706","article-title":"Association between steady\u2010state lactate dehydrogenase levels and sickle cell complications: a systematic review","volume":"15","author":"Mohamed S","year":"2025","journal-title":"Avicenna J Med"},{"key":"e_1_2_12_44_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/20469047.2017.1311087","article-title":"Haemoglobin oxygen saturation, leucocyte count and lactate dehydrogenase are predictors of elevated cerebral blood flow velocity in Nigerian children with sickle cell anaemia","volume":"38","author":"Ojewunmi O","year":"2018","journal-title":"Paediatr Int Child Health"},{"key":"e_1_2_12_45_1","doi-asserted-by":"crossref","first-page":"e1628","DOI":"10.1542\/peds.2007-2771","article-title":"A simple index using age, hemoglobin, and aspartate transaminase predicts increased intracerebral blood velocity as measured by transcranial Doppler scanning in children with sickle cell anemia","volume":"121","author":"Rees D","year":"2008","journal-title":"Pediatrics"},{"issue":"6","key":"e_1_2_12_46_1","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1182\/blood-2005-06-2373","article-title":"Lactate dehydrogenase as a biomarker of hemolysis\u2010associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease","volume":"107","author":"Kato GJ","year":"2006","journal-title":"Blood"},{"key":"e_1_2_12_47_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cca.2016.04.035","article-title":"Lactate dehydrogenase in sickle cell disease","volume":"458","author":"Stankovic Stojanovic K","year":"2016","journal-title":"Clin Chim Acta"},{"issue":"6","key":"e_1_2_12_48_1","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.thromres.2013.10.006","article-title":"Markers of endothelial dysfunction differ between subphenotypes in children with sickle cell disease","volume":"132","author":"Land V","year":"2013","journal-title":"Thromb Res"},{"issue":"22","key":"e_1_2_12_49_1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1182\/blood.V114.22.262.262","article-title":"Elevated systolic blood pressure and low fetal hemoglobin are risk factors for silent cerebral infarcts in children with sickle cell anemia","volume":"114","author":"Sarnaik SA","year":"2009","journal-title":"Blood"},{"issue":"6","key":"e_1_2_12_50_1","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1182\/blood-2003-07-2475","article-title":"Sustained long\u2010term hematologic efficacy of hydroxyurea at maximum tolerated dose in children with sickle cell disease","volume":"103","author":"Zimmerman SA","year":"2004","journal-title":"Blood"},{"issue":"12","key":"e_1_2_12_51_1","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1182\/blood-2009-05-221333","article-title":"The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17\u2010year, single\u2010center trial (LaSHS)","volume":"115","author":"Voskaridou E","year":"2010","journal-title":"Blood"},{"key":"e_1_2_12_52_1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bcmd.2017.08.017","article-title":"Real\u2010life experience with hydroxyurea in sickle cell disease: a multicenter study in a cohort of patients with heterogeneous descent","volume":"69","author":"Rigano P","year":"2018","journal-title":"Blood Cells Mol Dis"},{"issue":"1","key":"e_1_2_12_53_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/ajh.24587","article-title":"Hydroxyurea effectiveness in children and adolescents with sickle cell anemia: a large retrospective, population\u2010based cohort","volume":"92","author":"Quarmyne MO","year":"2017","journal-title":"Am J Hematol"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70830","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70830","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70830","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:41:45Z","timestamp":1789350105000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,13]]},"references-count":52,"alternative-id":["10.1111\/bjh.70830"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70830","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,13]]},"assertion":[{"value":"2026-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"bjh.70830"}}