{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:42:08Z","timestamp":1792629728151,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Cutaneous T\u2010cell lymphoma is staged by the degree of skin, lymph node, viscera and blood involvement. Skin response is a determinant of treatment decisions. Mogamulizumab, an anti\u2010CC chemokine receptor 4 antibody, is approved for mycosis fungoides and S\u00e9zary syndrome after \u22651 systemic therapy. Longitudinal changes in modified Severity\u2010Weighted Assessment Tool (mSWAT) score, and cluster of differentiation (CD)4\n                    <jats:sup>+<\/jats:sup>\n                    CD7\n                    <jats:sup>\u2212<\/jats:sup>\n                    \/CD26\n                    <jats:sup>\u2212<\/jats:sup>\n                    cell subsets during mogamulizumab treatment were investigated as an exploratory post\u2010hoc analysis. While chronological differences in mSWAT scores were not interpreted by a linear mixed model (LMM) due to a statistically significant interaction term, significant differences based on responses in CD7\n                    <jats:sup>\u2212<\/jats:sup>\n                    (\u2212690.5\/\u03bcL; 95% confidence interval [CI], \u22121195 to \u2212186.2;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0076) and CD26\n                    <jats:sup>\u2212<\/jats:sup>\n                    (\u22121029\/\u03bcL; 95% CI, \u22121705 to \u2212353.7;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0030) cell counts were identified. Actual values of mSWAT scores decreased for responders at Week (W) 12 and 24 from baseline (BL) (mean\u2009\u00b1\u2009standard error: BL: 97.57\u2009\u00b1\u20096.52; W12: 52.34\u2009\u00b1\u20096.16; W24: 34.89\u2009\u00b1\u20094.93) following a rapid decrease of CD7\n                    <jats:sup>\u2212<\/jats:sup>\n                    cells in blood at W4 (BL: 2809\u2009\u00b1\u2009650.3\/\u03bcL; W4: 204.4\u2009\u00b1\u200950.76\/\u03bcL; W12: 101.9\u2009\u00b1\u200928.81\/\u03bcL; W24: 152.8\u2009\u00b1\u200954.98\/\u03bcL). Monitoring both blood and skin improvements is important for effective mogamulizumab treatment in patients with advanced stage disease.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70879","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:06:07Z","timestamp":1792627567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mogamulizumab efficacy on the skin compartment of cutaneous T\u2010cell lymphomas based on longitudinal analysis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9826-7616","authenticated-orcid":false,"given":"Nobuaki","family":"Nakano","sequence":"first","affiliation":[{"name":"Seifukai Clinic  Miyakonojo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0623-9365","authenticated-orcid":false,"given":"Kenta","family":"Murotani","sequence":"additional","affiliation":[{"name":"Biostatistics Center, Kurume University  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9877-7362","authenticated-orcid":false,"given":"Yoshito","family":"Ohya","sequence":"additional","affiliation":[{"name":"Kyowa Kirin Co., Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4677-2343","authenticated-orcid":false,"given":"Yukihiro","family":"Nishio","sequence":"additional","affiliation":[{"name":"Kyowa Kirin Co., Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25577"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2023.113343"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.0630"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202049043"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201009\u20102697"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17523"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020009346"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.15639"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(18)30379\u20106"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2021.1953007"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.177279"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021012057"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.52.0924"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201009\u2010600924"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.616"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022018669"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201006\u20102672"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008241"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010043"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13487"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2025.2542941"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13338"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024027902"}],"container-title":["British 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