{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:45:13Z","timestamp":1792111513304,"version":"4.4.0"},"reference-count":60,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004031","name":"Jichi Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K07070"],"award-info":[{"award-number":["JP21K07070"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008670","name":"Terumo Foundation for Life Sciences and Arts","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008670","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24ek0510046"],"award-info":[{"award-number":["JP24ek0510046"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Th17, a subset of helper T cells that produce interleukin\u201017 (IL\u201017), is thought to play a pivotal role in the pathogenesis of chronic graft\u2010versus\u2010host disease (GVHD). However, the kinetics of Th17 following allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT) have not been elucidated. In this study, we evaluated the temporal dynamics and diversity of peripherally circulating Th17 after allo\u2010HSCT. The study included 86 patients who survived without disease relapse for 1\u2009year or more, and for whom peripheral blood samples 3\u2009months after allo\u2010HSCT were available. Th17 was detected and sorted by flow cytometry, and T\u2010cell receptor (TCR) repertoire was analysed by a next\u2010generation sequencing (NGS) method. Patients with chronic GVHD showed a higher TCR repertoire diversity, while those with severe chronic GVHD showed a lower TCR diversity and Th17\/Cluster of Differentiation (CD) 4 ratio. The amino acid sequence in complementarity determining region 3 of Th17\u2010TCR was not apparently different between patients with and without chronic GVHD. Additionally, a higher Th17\/CD4 ratio at 3\u2009months was related to a lower incidence of subsequent chronic GVHD. The current study explored the kinetics of peripherally circulating Th17 after allo\u2010HSCT, which might be associated with the development of chronic GVHD.<\/jats:p>","DOI":"10.1111\/bjh.70881","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:01:56Z","timestamp":1792108916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Repertoire diversity and dynamics of peripheral Th17 after allogeneic haematopoietic stem cell transplantation"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5899-7913","authenticated-orcid":false,"given":"Masaharu","family":"Tamaki","sequence":"first","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center  Saitama Japan"},{"name":"Division of Emerging Medicine for Integrated Therapeutics, Center for Molecular Medicine Jichi Medical University  Shimotsuke 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