{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T09:41:10Z","timestamp":1792489270433,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2510500"],"award-info":[{"award-number":["2024YFC2510500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    To describe outcomes after haematopoietic stem cell transplantation (HSCT) and non\u2010transplant treatment in patients with classical paroxysmal nocturnal haemoglobinuria (cPNH) without access to complement inhibitors, we analysed 227 patients with cPNH treated at 10 centres between January 1976 and April 2022. Among them, 51 underwent HSCT and 176 received non\u2010transplant treatment without complement inhibitors. At 6\u2009months post\u2010treatment, 96.08% of HSCT patients achieved normal complete blood count, compared to 3.41% in the non\u2010HSCT cohort (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Estimated 5\u2010year overall survival (OS) did not differ significantly between HSCT and non\u2010HSCT cohorts (92.16% vs. 98.83%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.097). Five\u2010year failure\u2010free survival (FFS) was 92.16% in the HSCT cohort and 0.57% in the non\u2010HSCT cohort (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Delayed platelet engraftment\u2010free, graft\u2010versus\u2010host disease\u2010free, failure\u2010free survival did not differ significantly between HSCT performed within 12\u2009months after diagnosis and later transplantation (83.33% vs. 62.34%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.136). In addition, alternative donor HSCT achieved OS and FFS comparable to matched sibling donor HSCT. This study reports outcomes after HSCT and non\u2010transplant treatment in a historical setting without access to complement inhibitors. However, further studies are needed to clarify the role and indications for HSCT in cPNH in the complement inhibitor era.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70890","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T09:05:15Z","timestamp":1792487115000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Allogeneic transplantation versus non\u2010transplant treatment for classical paroxysmal nocturnal haemoglobinuria without complement inhibitors"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9060-6679","authenticated-orcid":false,"given":"Qingyuan","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Collaborative Innovation Center of Hematology The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Gu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Collaborative Innovation Center of Hematology The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Collaborative Innovation Center of Hematology The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Collaborative Innovation Center of Hematology The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Huai'an Hospital of Xuzhou Medical University and The Second People's Hospital of Huai'an  Huai'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Guangzhou First People's Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erlie","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases Institute of Hematology &amp; Blood Diseases Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuewen","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Hematology Henan Tumor Hospital, Institute of Hematology, Affiliated Cancer Hospital Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqing","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Hematology Haikou Municipal People's Hospital, Affiliated Haikou Hospital Xiangya School of Medicine Central South University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Fourth Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Collaborative Innovation Center of Hematology The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Miao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Collaborative Innovation Center of Hematology The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6312-3863","authenticated-orcid":false,"given":"Depei","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Collaborative Innovation Center of Hematology The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9006-5155","authenticated-orcid":false,"given":"Limin","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Collaborative Innovation Center of Hematology The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"issue":"2","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00005792-199703000-00001","article-title":"Paroxysmal nocturnal hemoglobinuria as a molecular disease","volume":"76","author":"Rosse WF","year":"1997","journal-title":"Medicine (Baltimore)"},{"issue":"10","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1182\/blood.2019003812","article-title":"How I treat 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A cost\u2010effectiveness analysis of eculizumab versus allogeneic stem cell transplant","volume":"124","author":"Marchetti M","year":"2014","journal-title":"Blood"},{"issue":"4","key":"e_1_2_11_33_1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/ajh.24278","article-title":"Impact of eculizumab treatment on paroxysmal nocturnal hemoglobinuria: a treatment versus no\u2010treatment study","volume":"91","author":"Loschi M","year":"2016","journal-title":"Am J Hematol"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70890","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70890","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T09:05:19Z","timestamp":1792487119000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,20]]},"references-count":32,"alternative-id":["10.1111\/bjh.70890"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70890","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,20]]},"assertion":[{"value":"2026-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"bjh.70890"}}