{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:41:07Z","timestamp":1792374067014,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["U01HL163983"],"award-info":[{"award-number":["U01HL163983"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA021765"],"award-info":[{"award-number":["P30CA021765"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Allogeneic haematopoietic stem cell transplantation (HSCT) is curative for sickle cell disease (SCD) \u2010 a group of inherited haemoglobin disorders encompassing homozygous haemoglobin S (HbSS) and compound heterozygous sickling disorders, including haemoglobin SC disease (HbSC), haemoglobin S\/\u03b2\n                    <jats:sup>0<\/jats:sup>\n                    \u2010thalassaemia (HbS\u03b2\n                    <jats:sup>0<\/jats:sup>\n                    ), haemoglobin S\/\u03b2\n                    <jats:sup>+<\/jats:sup>\n                    \u2010thalassaemia (HbS\u03b2\n                    <jats:sup>+<\/jats:sup>\n                    ), etc.,\u00a0but its long\u2010term impact on SCD myocardial remodelling is incompletely characterized. We performed serial cardiac magnetic resonance imaging (CMR) and echocardiography in children and young adults with SCD undergoing matched\u2010sibling or haploidentical HSCT in a prospective clinical trial with up to 36\u2009months of post\u2010HSCT follow\u2010up. CMR assessments were conducted before HSCT and through the post\u2010HSCT period. Echocardiographic parameters at 12\u2009months post HSCT were compared with those of age\u2010matched participants receiving disease\u2010modifying therapies (DMTs). Among 20 HSCT recipients (mean age 14.8\u2009years), CMR demonstrated progressive reductions in biventricular volumes and left atrial volume over 36\u2009months, with preservation of ejection fraction. Extra\u2010cellular volume, a surrogate marker of myocardial fibrosis, showed significant improvement from baseline, having normalized in nearly all participants assessed at 36\u2009months. Compared with age\u2010matched DMT recipients, HSCT recipients had lower tricuspid regurgitant jet velocity and improved diastolic parameters at 12\u2009months post\u2010HSCT, with normalization of cardiac output on echocardiography. These findings demonstrate sustained reversal of myocardial fibrosis and structural cardiac remodelling after HSCT for SCD. HSCT may, therefore, modify the trajectory of SCD cardiomyopathy beyond the improvements achieved with current DMTs.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70891","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:21:37Z","timestamp":1792372897000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sustained improvement in sickle cell cardiomyopathy after haematopoietic stem cell transplantation is superior to that with disease\u2010modifying therapy"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5770-7280","authenticated-orcid":false,"given":"Parul","family":"Rai","sequence":"first","affiliation":[{"name":"Department of Hematology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3802-488X","authenticated-orcid":false,"given":"Subodh","family":"Selukar","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6484-2034","authenticated-orcid":false,"given":"Yu","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6228-0229","authenticated-orcid":false,"given":"Anthony","family":"Merlocco","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology The University of Tennessee Health Science Center  Memphis Tennessee USA"},{"name":"Division of Pediatric Radiology The University of Tennessee Health Science Center  Memphis Tennessee USA"},{"name":"Department of Radiology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1953-4486","authenticated-orcid":false,"given":"Cara E.","family":"Morin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology Cincinnati Children's Hospital  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Goode","sequence":"additional","affiliation":[{"name":"Department of Radiology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4182-2786","authenticated-orcid":false,"given":"Jeffrey A.","family":"Towbin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology The University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2884-4163","authenticated-orcid":false,"given":"Mark","family":"Rushing","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology The University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1576-441X","authenticated-orcid":false,"given":"Michael A.","family":"Rebolledo","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology The University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya","family":"Joshi","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology The University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4317-3879","authenticated-orcid":false,"given":"Alexis","family":"Leonard","sequence":"additional","affiliation":[{"name":"Department of Hematology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4439-7321","authenticated-orcid":false,"given":"Jane S.","family":"Hankins","sequence":"additional","affiliation":[{"name":"Department of Hematology St. Jude Children's Research Hospital  Memphis Tennessee USA"},{"name":"Department of Global Pediatric Medicine St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Manwani","sequence":"additional","affiliation":[{"name":"Department of Hematology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2832-6884","authenticated-orcid":false,"given":"Clifford M.","family":"Takemoto","sequence":"additional","affiliation":[{"name":"Department of Hematology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3991-7468","authenticated-orcid":false,"given":"Stephen","family":"Gottschalk","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation and Cellular Therapy St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8220-9980","authenticated-orcid":false,"given":"Brandon","family":"Triplett","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation and Cellular Therapy St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0712-1123","authenticated-orcid":false,"given":"Jason N.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology The University of Tennessee Health Science Center  Memphis Tennessee USA"},{"name":"Division of Pediatric Radiology The University of Tennessee Health Science Center  Memphis Tennessee 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