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Conventional approaches to identifying rare blood group donors rely on targeted screening and laborious laboratory studies, which are limited by resource constraints and insufficient population diversity. The aim of this study was to enhance the identification of rare blood group donors in Finland by utilizing genome\u2010wide data from our national Blood Service Biobank. Genomic variants associated with rare phenotypes were screened in 56\u2009997 blood donors, after which the rare blood group was confirmed using routine methods. To estimate the need for rare blood group units, we utilized data from the Helsinki University Hospital (HUS) Data Lake and the laboratory information system of the HUS Blood Bank. Eighty\u2010six new rare donors were identified, with complete concordance between genomic results and confirmed phenotypes. Patient data highlighted donor needs and identified rare phenotypes, particularly those more prevalent among individuals of African ancestry. These findings demonstrate the value of biobank genomic data in expanding rare donor registries and improving transfusion preparedness.<\/jats:p>","DOI":"10.1111\/bjh.70893","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T02:02:21Z","timestamp":1792375341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of rare blood group donors from biobank data"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7060-8675","authenticated-orcid":false,"given":"Inna","family":"Sareneva","sequence":"first","affiliation":[{"name":"Finnish Red Cross Blood Service  Vantaa Finland"},{"name":"Department of Clinical Chemistry, Diagnostic Center Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7355-2354","authenticated-orcid":false,"given":"Lotta","family":"Joutsi\u2010Korhonen","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Diagnostic Center Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9525-0787","authenticated-orcid":false,"given":"Tomi","family":"Virtanen","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Diagnostic Center Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3605-2405","authenticated-orcid":false,"given":"Tuulia","family":"Palukka","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service  Vantaa Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Blood Service Biobank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4117-0458","authenticated-orcid":false,"given":"Anna","family":"Lempi\u00e4inen","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Diagnostic Center Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaana","family":"M\u00e4tt\u00f6","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service  Vantaa Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4605-2837","authenticated-orcid":false,"given":"Kati","family":"Hyv\u00e4rinen","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service, R&amp;D, Biomedicum Helsinki 1  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8904-666X","authenticated-orcid":false,"given":"Katri","family":"Haimila","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service  Vantaa Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12006"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1751\u20102824.2009.01245.X"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12357"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20103148.2002.00399.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/BJH.12061"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3283316bed"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2011.08576.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","unstructured":"TormeyCA HendricksonJE.Review series transfusion\u2010related red blood cell alloantibodies: induction and consequences [Internet]. 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