{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:40:53Z","timestamp":1792204853186,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100025520","name":"Medical Research Future Fund","doi-asserted-by":"publisher","award":["MRF\/2007620"],"award-info":[{"award-number":["MRF\/2007620"]}],"id":[{"id":"10.13039\/501100025520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Co\u2010designed research in paediatric HSCT is limited. We sought to determine research priorities which represent the shared priorities of patients, parents, carers and healthcare professionals (HCP) within Australia, New Zealand, the Netherlands and the United Kingdom. An international, multiphase priority\u2010setting methodology was implemented in partnership with the James Lind Alliance and delivered over an 18\u2010month period. Part 1: an international scoping survey asked respondents to submit their research uncertainties related to paediatric HSCT. Part 2: summarising and evidence\u2010checking the submitted uncertainties. Part 3: interim prioritisation survey. Part 4: consensus workshop. In the first international scoping survey, 667 topic ideas were suggested (45% by consumers, 55% by HCP), which were categorised into 80 summary questions. After systematic literature review, 35 summary questions were judged to be true uncertainties (i.e. not answered by existing evidence). These 35 uncertainties were included in a second interim prioritisation survey and completed by 224 participants. From those, a shortlist of 19 questions was drawn. After a multistakeholder workshop, consensus was reached on the top 10 priorities. The PSP identified important research gaps in the management of paediatric HSCT. Priority areas included: implementing personalised medicine approaches, improving immune recovery and adjunct interventions such as exercise, nutrition and microbiome\u2010directed strategies.<\/jats:p>","DOI":"10.1111\/bjh.70901","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:51:23Z","timestamp":1792201883000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Paediatric haematopoietic stem cell transplantation research priorities: Results from an international multi\u2010stakeholder priority setting partnership"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7692-2837","authenticated-orcid":false,"given":"Elizabeth","family":"Williams","sequence":"first","affiliation":[{"name":"Cancer Therapies Group Murdoch Children's Research Institute  Melbourne Australia"},{"name":"Children's Cancer Centre The Royal Children's Hospital Melbourne  Melbourne Australia"},{"name":"Department of Paediatrics The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1826-2257","authenticated-orcid":false,"given":"Roxanne","family":"Dyas","sequence":"additional","affiliation":[{"name":"Cancer Therapies Group Murdoch Children's Research Institute  Melbourne Australia"},{"name":"Children's Cancer Centre The Royal Children's Hospital Melbourne  Melbourne Australia"},{"name":"Department of Paediatrics The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3062-4506","authenticated-orcid":false,"given":"Katherine","family":"Colman","sequence":"additional","affiliation":[{"name":"Children's Cancer Centre The Royal Children's Hospital Melbourne  Melbourne 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Blood and Cancer Centre, Starship Child Health Te Whatu Ora, Health  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6218-1324","authenticated-orcid":false,"given":"Andrew R.","family":"Gennery","sequence":"additional","affiliation":[{"name":"Great North Children's Hospital Newcastle upon Tyne Hospital NHS Foundation Trust  Newcastle upon Tyne UK"},{"name":"Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5407-7829","authenticated-orcid":false,"given":"Mary","family":"Slatter","sequence":"additional","affiliation":[{"name":"Great North Children's Hospital Newcastle upon Tyne Hospital NHS Foundation Trust  Newcastle upon Tyne UK"},{"name":"Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Chait\u2010Rubinek","sequence":"additional","affiliation":[{"name":"Children's Cancer Centre The Royal Children's Hospital Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7643-8592","authenticated-orcid":false,"given":"Eileen","family":"Van Der Stoep","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy and Toxicology Leiden University Medical Centre  Leiden The Netherlands"},{"name":"Centre for Cell and Gene Therapy Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6703-2993","authenticated-orcid":false,"given":"Arjan","family":"Lankester","sequence":"additional","affiliation":[{"name":"Willem\u2010Alexander Children's Hospital Leiden University Medical Centre  Leiden The 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Melbourne  Parkville Victoria Australia"},{"name":"Infectious Disease Department The Royal Children's Hospital  Melbourne Australia"},{"name":"Clinical Infections Murdoch Children's Research Institute  Melbourne Australia"},{"name":"Department of Infectious Diseases Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5608-2728","authenticated-orcid":false,"given":"Lisa M.","family":"Ott de Bruin","sequence":"additional","affiliation":[{"name":"Willem\u2010Alexander Children's Hospital Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4078-5001","authenticated-orcid":false,"given":"Tim","family":"Prestidge","sequence":"additional","affiliation":[{"name":"Starship Blood and Cancer Centre, Starship Child Health Te Whatu Ora, Health  Auckland New 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Children's Hospital Melbourne  Melbourne Australia"},{"name":"James Lind Alliance, NIHR Evaluation, Trials and Studies Coordinating Centre  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the James Lind Alliance Priority Setting Partnership in Paediatric Haematopoietic Stem Cell Transplantation Steering Committee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"issue":"17","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1056\/NEJMra052638","article-title":"Hematopoietic stem\u2010cell transplantation","volume":"354","author":"Copelan EA","year":"2006","journal-title":"N Engl J Med"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3389\/fimmu.2016.00470","article-title":"Milestones of hematopoietic stem cell transplantation \u2010 from first human studies to current 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intensive care unit","volume":"13","author":"Schober S","year":"2023","journal-title":"Front Oncol"},{"key":"e_1_2_11_7_1","volume-title":"Annual activity report 2023","author":"British Society of Blood and Marrow Transplantation and Cellular Therapy (BSBMTCT)","year":"2023"},{"key":"e_1_2_11_8_1","volume-title":"Annual report 2022","author":"European Society for Blood and Marrow Transplantation (EBMT)","year":"2022"},{"issue":"5","key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"321.e1","DOI":"10.1016\/j.jtct.2025.01.894","article-title":"Co\u2010designing a novel ordinal endpoint for an adaptive platform trial, BANDICOOT, in pediatric hematopoietic stem cell transplant","volume":"31","author":"Walker H","year":"2025","journal-title":"Transplant Cell Ther"},{"issue":"4","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3324\/haematol.2020.247395","article-title":"The clinical role of the gut microbiome and fecal microbiota transplantation in 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Southampton (UK): National Institute for Health and Care Research (NIHR).2024. Available from:https:\/\/www.jla.nihr.ac.uk\/jla\u2010guidebook."},{"issue":"5","key":"e_1_2_11_17_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2024-085115","article-title":"Minimising adverse drug reactions and verifying economic legitimacy\u2010pharmacogenomics implementation in children (MARVEL\u2010 PIC): protocol for a national randomised controlled trial of pharmacogenomics implementation","volume":"14","author":"Conyers R","year":"2024","journal-title":"BMJ Open"},{"issue":"8","key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jtct.2025.05.014","article-title":"Current activity trends and outcomes in hematopoietic cell transplantation and cellular therapy \u2010 a report from the CIBMTR","volume":"31","author":"Spellman SR","year":"2025","journal-title":"Transplant Cell Ther"},{"issue":"8","key":"e_1_2_11_19_1","doi-asserted-by":"crossref","first-page":"18601","DOI":"10.3390\/ijms160818601","article-title":"Role of pharmacogenetics 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