{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T02:40:19Z","timestamp":1792377619302,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2508900"],"award-info":[{"award-number":["2023YFC2508900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370183"],"award-info":[{"award-number":["82370183"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["23JCZXJC00310"],"award-info":[{"award-number":["23JCZXJC00310"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018904","name":"Beijing Xisike Clinical Oncology Research Foundation","doi-asserted-by":"publisher","award":["Y\u2010SYBLD2022ZD\u20100031"],"award-info":[{"award-number":["Y\u2010SYBLD2022ZD\u20100031"]}],"id":[{"id":"10.13039\/100018904","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"abstract":"Summary<\/jats:title>\n \n Colony\u2010stimulating factor 3 receptor (\n CSF3R<\/jats:italic>\n ) mutations occur in acute myeloid leukaemia (AML), but their prognostic significance remains unclear. We analysed 2500 patients with newly diagnosed de novo non\u2010acute promyelocytic leukaemia (APL) AML treated with intensive induction therapy.\n CSF3R<\/jats:italic>\n mut<\/jats:sup>\n were identified in 3.5% and frequently co\u2010occurred with CCAAT\/enhancer\u2010binding protein alpha bZIP domain (\n CEBPA\u2010bZip<\/jats:italic>\n ) mutations and RUNX family transcription factor 1::RUNX1 partner transcriptional co\u2010repressor 1 (\n RUNX1::RUNX1T1<\/jats:italic>\n ) fusions. In the entire cohort,\n CSF3R<\/jats:italic>\n mut<\/jats:sup>\n were associated with inferior relapse\u2010free survival (RFS), but not overall survival (OS) or event\u2010free survival (EFS). The prognostic impact was context\u2010dependent. The adverse association was most consistent in\n CEBPA\u2010bZip<\/jats:italic>\n AML, with inferior OS, EFS (hazard ratio [HR], 2.76;\n p<\/jats:italic>\n \u2009=\u20090.001) and RFS (HR, 2.66;\n p<\/jats:italic>\n \u2009=\u20090.002) and persisted after multivariable adjustment and time\u2010dependent modelling of transplantation. Membrane\u2010proximal activating mutations (MPM) were associated primarily with inferior RFS (HR, 2.27;\n p<\/jats:italic>\n \u2009=\u20090.001) in the overall cohort, whereas cytoplasmic\u2010tail truncating mutations (CTTM) showed no consistent adverse effect. In\n CEBPA\u2010bZip<\/jats:italic>\n AML, both MPM and CTTM showed adverse EFS and RFS associations, although the CTTM subgroup was small. The prognostic impact of\n CSF3R<\/jats:italic>\n mut<\/jats:sup>\n in AML depends on molecular context and functional mutation class, with the strongest adverse associations observed in\n CEBPA\u2010bZi<\/jats:italic>\n p AML.\n <\/jats:p>","DOI":"10.1111\/bjh.70909","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:56:06Z","timestamp":1792374966000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Subtype\u2010 and functional class\u2010dependent prognostic impact of\n \n CSF3R<\/i>\n <\/scp>\n mutations in acute myeloid leukaemia: A cohort study of 2500 patients"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7115-6841","authenticated-orcid":false,"given":"Jingyao","family":"An","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7976-0601","authenticated-orcid":false,"given":"Yan","family":"Hui","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7485-0954","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7041-8064","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benfa","family":"Gong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuntao","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouyun","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1532-0301","authenticated-orcid":false,"given":"Kaiqi","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangji","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlin","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8938-3081","authenticated-orcid":false,"given":"Xiaoyuan","family":"Gong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3866-0066","authenticated-orcid":false,"given":"Shaowei","family":"Qiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9011-0777","authenticated-orcid":false,"given":"Bingcheng","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchang","family":"Mi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4985-052X","authenticated-orcid":false,"given":"Qiuyun","family":"Fang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9437-9151","authenticated-orcid":false,"given":"Jianxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1674-3792","authenticated-orcid":false,"given":"Hui","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-018-0566-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01424-6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-020-00161-7"},{"issue":"1","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13045-024-01571-4","article-title":"A practical approach on the classifications of myeloid neoplasms and acute leukemia: WHO and ICC","volume":"17","author":"Xiao W","year":"2024","journal-title":"J Hematol Oncol"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.6.1737.1737"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2741\/2103"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.8.2985"},{"issue":"6","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1182\/blood.V84.6.1760.1760","article-title":"Rapid activation of the STAT3 transcription factor by granulocyte colony\u2010stimulating factor","volume":"84","author":"Tian SS","year":"1994","journal-title":"Blood"},{"issue":"11","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1073\/pnas.91.11.4683","article-title":"Granulocyte colony\u2010stimulating factor receptor signaling involves the formation of a three\u2010component complex with Lyn and Syk protein\u2010tyrosine kinases","volume":"91","author":"Corey SJ","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.6.3230"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00093"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.4.683"},{"issue":"3","key":"e_1_2_10_14_1","first-page":"946","article-title":"Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5","volume":"118","author":"Liu F","year":"2008","journal-title":"J Clin Invest"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214514"},{"issue":"1","key":"e_1_2_10_16_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41408-026-01532-9","article-title":"Gene\u2010 and subtype\u2010dependent prognostic impact of RAS pathway mutations in acute myeloid leukemia: a cohort study of 2,500 patients","volume":"16","author":"Shen H","year":"2026","journal-title":"Blood Cancer J"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2021.11.013"},{"issue":"1","key":"e_1_2_10_18_1","first-page":"263","article-title":"Distribution of different classes of CSF3R mutations and co\u2010mutational pattern in 360 myeloid neoplasia","volume":"104","author":"Maffei R","year":"2025","journal-title":"Ann Hematol"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23873"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31586"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-019-0133-7"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-3433"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.267526"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-04-709899"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-705053"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13364-2"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.09.036"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16535"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18113"},{"issue":"8","key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1101\/gad.4.8.1416","article-title":"Identification of two polypeptide segments of CCAAT\/enhancer\u2010binding protein required for transcriptional activation of the serum albumin gene","volume":"4","author":"Friedman AD","year":"1990","journal-title":"Genes Dev"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.9.4717"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.4.1234.bloodjournal8841234"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1546"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2280"},{"issue":"12","key":"e_1_2_10_35_1","first-page":"3140","article-title":"CSF3R mutations and variants in myeloid neoplasms: associated phenotypes, co\u2010mutations, and survival trends","volume":"110","author":"Bolarinwa A","year":"2025","journal-title":"Haematologica"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-509976"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.508440"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01062-w"},{"issue":"10","key":"e_1_2_10_39_1","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.3324\/haematol.2013.090571","article-title":"Severe congenital neutropenia and chronic neutrophilic leukemia: an intriguing molecular connection unveiled by oncogenic mutations in CSF3R","volume":"98","author":"Touw IP","year":"2013","journal-title":"Haematologica"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70909","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70909","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:56:14Z","timestamp":1792374974000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,18]]},"references-count":38,"alternative-id":["10.1111\/bjh.70909"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70909","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,18]]},"assertion":[{"value":"2026-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"bjh.70909"}}