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The condition has been associated with a variety of cognitive and perceptual advantages, including benefits in memory, processing speed, and creativity. It is not currently recognized in the\n                    <jats:styled-content style=\"fixed-case\">DSM<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                    . Recently, however, several studies have raised the question of a possible link between synaesthesia and clinical conditions. Here, we present the first large\u2010scale screening of the general population in which we (1) objectively identified grapheme\u2010colour synaesthetes and (2) elicited information from our participants about a range of clinical conditions. We compared the prevalence rates of these conditions in synaesthetes versus non\u2010synaesthetes to establish whether any conditions were found at a higher rate among synaesthetes. In our initial study, screening 3,742 people (95 synaesthetes and 3,647 controls), we found initially that grapheme\u2010colour was significantly comorbid with two conditions (anxiety disorder and obsessive compulsive disorder). In our second study, screening a new population of 120 synaesthetes and 166 non\u2010synaesthetes, we replicated our finding that grapheme\u2010colour synaesthesia is comorbid with anxiety disorder. At the same time, we also addressed a methodological concern that likely elevated rates of\n                    <jats:styled-content style=\"fixed-case\">OCD<\/jats:styled-content>\n                    in Study 1. We consider the aetiology of synaesthesia to determine whether there may be a shared genetic or neurological basis with anxiety disorder, and we question the status of synaesthesia within a mental health framework.\n                  <\/jats:p>","DOI":"10.1111\/bjop.12354","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T10:54:07Z","timestamp":1538736847000},"page":"530-548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Is there a burden attached to synaesthesia? 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