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We conducted a systematic review of randomized controlled trials (RCTs) and cost\u2010effectiveness studies assessing PTSD symptoms in adults, published since the NICE 2018 guidelines. EMDR was compared with trauma\u2010focused\u2010cognitive behavioural therapy (TF\u2010CBT), waitlist or usual care. Six databases were searched in September 2023. Risk of bias was assessed. Data synthesis included Bayesian meta\u2010analyses of standardized mean differences if sufficient data were available from at least three RCTs. From 2038 records, 17 studies met the eligibility criteria. One modelling\u2010based study reported cost\u2010effectiveness, finding EMDR the most cost\u2010effective intervention compared to 10 others, including TF\u2010CBT. Sixteen RCTs (<jats:italic>n<\/jats:italic>\u2009=\u20091031) providing clinical PTSD outcome data were identified. Most studies had small sample sizes, and all but one was at high\/moderate risk of bias. Additionally, 13 RCTs from NICE 2018 guidelines contributed to meta\u2010analyses. EMDR treatment was generally of shorter duration with a lower burden on patient time. Meta\u2010analyses found EMDR was statistically significantly better than waitlist\/usual care. There was no significant difference in treatment effect between EMDR and TF\u2010CBT, both reported significantly improved PTSD symptoms.<\/jats:p>","DOI":"10.1111\/bjop.70005","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T11:24:29Z","timestamp":1751714669000},"page":"1128-1149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical and cost\u2010effectiveness of eye movement desensitization and reprocessing for treatment and prevention of post\u2010traumatic stress disorder in adults: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7353-5979","authenticated-orcid":false,"given":"Emma","family":"Simpson","sequence":"first","affiliation":[{"name":"Sheffield Centre for Health and Related Research (SCHARR) University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Carroll","sequence":"additional","affiliation":[{"name":"Sheffield Centre for Health and Related Research (SCHARR) University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2449-2516","authenticated-orcid":false,"given":"Anthea","family":"Sutton","sequence":"additional","affiliation":[{"name":"Sheffield Centre for Health and Related Research (SCHARR) University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Forsyth","sequence":"additional","affiliation":[{"name":"Sheffield Centre for Health and Related Research (SCHARR) University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabel","family":"Rayner","sequence":"additional","affiliation":[{"name":"Sheffield Centre for Health and Related Research (SCHARR) University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Ren","sequence":"additional","affiliation":[{"name":"Sheffield Centre for Health and Related Research (SCHARR) University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Franklin","sequence":"additional","affiliation":[{"name":"Sheffield Centre for Health and Related Research (SCHARR) University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Wood","sequence":"additional","affiliation":[{"name":"Sheffield Centre for Health and Related Research (SCHARR) University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3402\/ejpt.v6.27414"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291716001070"},{"issue":"3","key":"e_1_2_9_4_1","first-page":"146","article-title":"The efficacy of eye movement desensitization reprocessing in resolving the trauma caused by the road accidents in the Slutanate of Oman","volume":"39","author":"Aldahadha B.","year":"2012","journal-title":"Journal of Instructional Psychology"},{"key":"e_1_2_9_5_1","volume-title":"Practice guidelines for the treatment of patients with acute stress disorder and posttraumatic stress disorder","author":"American Psychiatric Association","year":"2010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10163708"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/17511437221136828"},{"issue":"12","key":"e_1_2_9_8_1","article-title":"Psychological therapies for chronic post\u2010traumatic stress disorder (PTSD) in adults","volume":"2013","author":"Bisson J. 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