{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T02:09:42Z","timestamp":1775614182827,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2013,10]]},"abstract":"\n Objectives<\/jats:title>\n \n \n \n \n To report our experience with ureteroscopic laser ablation of upper tract urothelial carcinoma (\n UTUC<\/jats:styled-content>\n ) in patients with\n L<\/jats:styled-content>\n ynch\n S<\/jats:styled-content>\n yndrome (\n LS<\/jats:styled-content>\n ), as defined by a documented germline mutation in the\n \n MSH<\/jats:styled-content>\n \u20102\n <\/jats:italic>\n gene.\n <\/jats:p>\n <\/jats:list-item>\n \n \n To increase awareness among urologists about\n UTUC<\/jats:styled-content>\n in this unique patient population and refer to genetic counselling when appropriate.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n \n \n \n Demographic, clinical and pathological data on 13 consecutive patients with\n UTUC<\/jats:styled-content>\n and documented\n \n MSH<\/jats:styled-content>\n \u20102\n <\/jats:italic>\n mutation comprising 15 involved renal units were retrospectively collected.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Ureteroscopic evaluations involved biopsy and laser treatment with combination holmium\/neodymium yttrium aluminum garnet (\n YAG<\/jats:styled-content>\n ) lasers.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Tumours were graded from 1 to 3 according to the 1973\n W<\/jats:styled-content>\n orld\n H<\/jats:styled-content>\n ealth\n O<\/jats:styled-content>\n rganisation classification by a single pathologist evaluating cell block preparations.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n \n \n The mean patient age at initial presentation was 56.5 years, with six of 13 patients having metachronous bilateral\n UT<\/jats:styled-content>\n disease.\n <\/jats:p>\n <\/jats:list-item>\n \n The mean follow\u2010up was 59 months with a mean number of surveillances of 12.<\/jats:p>\n <\/jats:list-item>\n \n Of 15 affected renal units, 10\/15 (67%) of initial tumours involved the ureter with mean lesion size of 17.5\u2009mm, while five of 15 (33%) involved the intrarenal collecting system with mean lesion size of 25\u2009mm.<\/jats:p>\n <\/jats:list-item>\n \n Ureteroscopy cleared 13\/15 (87%) lesions and four of those 13 (31%) needed staged procedures. Renal preservation rate was 14\/15 (93%) with one nephroureterectomy and one segmental ureterectomy performed.<\/jats:p>\n <\/jats:list-item>\n \n \n One patient developed metastatic\n UTUC<\/jats:styled-content>\n after 40 months surveillance. No patient presented with bladder tumours but seven of the 13 (54%) developed them within 10 months of the initial ureteroscopy.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n \n \n Patients with\n LS<\/jats:styled-content>\n who develop\n UTUC<\/jats:styled-content>\n present at younger ages and appear to be more likely to have bilateral\n UT<\/jats:styled-content>\n disease over their lifetimes vs sporadic\n UTUC<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:list-item>\n \n Ureteroscopic laser ablation offers a good renal preservation rate with reasonable cancer control in patients willing to undergo endoscopic surveillance.<\/jats:p>\n <\/jats:list-item>\n \n Development of new bladder tumours is common.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n 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