{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:42:41Z","timestamp":1773268961888,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2013,7]]},"abstract":"\n Objective<\/jats:title>\n \n \n \n \n To ascertain current trends in the incidence and mortality rates for upper tract urothelial cancer (\n UTUC<\/jats:styled-content>\n ) and identify any relationship with age, stage at presentation, social deprivation and treatment method.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n \n \n \n We used national databases to collect the data: incidence, stage and survival data from the\n N<\/jats:styled-content>\n ational\n C<\/jats:styled-content>\n ancer\n D<\/jats:styled-content>\n ata\n R<\/jats:styled-content>\n epository (\n NCDR<\/jats:styled-content>\n ) and\n B<\/jats:styled-content>\n ritish\n A<\/jats:styled-content>\n ssociation of\n U<\/jats:styled-content>\n rological\n S<\/jats:styled-content>\n urgeons (\n BAUS<\/jats:styled-content>\n ) audit database; mortality data from the\n O<\/jats:styled-content>\n ffice for\n N<\/jats:styled-content>\n ational\n S<\/jats:styled-content>\n tatistics (\n ONS<\/jats:styled-content>\n ); and treatment method data from the\n H<\/jats:styled-content>\n ospital\n E<\/jats:styled-content>\n pisodes\n S<\/jats:styled-content>\n tatistics (\n HES<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n \n \n The incidence of\n UTUC<\/jats:styled-content>\n is increasing (from 1985 to 2009 it increased by 38% in men and 77% in women). It affects mainly those aged >60 years, and diagnoses are increasingly made in those aged >80 years. Diagnoses at advanced stage have increased from 45 to 80%.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Mortality has risen faster than incidence; the overall 5\u2010year survival rate has dropped from 60 to 48%. Survival is worst in stage\n IV<\/jats:styled-content>\n disease and in patients aged \u226580 years; when analysed by age or stage group, survival rates are unchanged.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Nephroureterectomy has increased by 75%, but endoscopic treatment, which only became available part way through the study period, now accounts for 11% of surgical interventions for\n UTUC<\/jats:styled-content>\n , mainly in stage\n I<\/jats:styled-content>\n disease and in the elderly.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n \n \n Despite sharing its risk factors with bladder cancer, current incidence and mortality trends for\n UTUC<\/jats:styled-content>\n contrast with those in bladder cancer. Increasing use of cross\u2010sectional imaging may explain some of the identified increased incidence. Higher incidence specifically in people >80 years, together with stage migration to more advanced cancers, are likely to have caused at least some of the observed increased mortality.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Further study is required to answer the questions of whether there are other hitherto unidentified aetiological or prognostic factors; whether less aggressive treatment of\n UTUCs<\/jats:styled-content>\n in the elderly is always justified; and whether the rising frequency of minimally invasive treatment means suboptimum oncological management.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12025","type":"journal-article","created":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T08:42:58Z","timestamp":1362645778000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Prognosis is deteriorating for upper tract urothelial cancer: data for\n E<\/scp>\n ngland 1985\u20132010"],"prefix":"10.1111","volume":"112","author":[{"given":"Maike F.","family":"Eylert","sequence":"first","affiliation":[{"name":"Department of Urology Morriston Hospital Swansea UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke","family":"Hounsome","sequence":"additional","affiliation":[{"name":"South West Public Health Observatory Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Verne","sequence":"additional","affiliation":[{"name":"South West Public Health Observatory Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Bahl","sequence":"additional","affiliation":[{"name":"Department of Oncology Bristol Haematology and Oncology Centre Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward R.","family":"Jefferies","sequence":"additional","affiliation":[{"name":"Department of Urology Cheltenham General Hospital Cheltenham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj A.","family":"Persad","sequence":"additional","affiliation":[{"name":"Department of Urology Bristol Royal Infirmary Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2009.05.013"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08889.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09675.x"},{"key":"e_1_2_8_5_1","first-page":"7","volume-title":"European Association of Urology Guidelines","author":"Roupr\u00eat M","year":"2011"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11068.x"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbju.12025","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.12025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:05:03Z","timestamp":1761746703000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.12025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,7]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/bju.12025"],"URL":"https:\/\/doi.org\/10.1111\/bju.12025","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,7]]},"assertion":[{"value":"2013-03-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}