{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:38:09Z","timestamp":1791326289368,"version":"4.3.1"},"reference-count":52,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T00:00:00Z","timestamp":1365724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2013,6]]},"abstract":"\n Objective<\/jats:title>\n \n \n \n \n To evaluate the efficacy and safety of long\u2010acting i.m. testosterone undecanoate (\n TU<\/jats:styled-content>\n ) in Malaysian men with testosterone deficiency (\n TD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n \n \n \n A total of 120 men, aged 40\u201370 years, with\n TD<\/jats:styled-content>\n (serum total testosterone [\n TT<\/jats:styled-content>\n ] \u2264 12\u2009nmol\/L) were randomised to receive either i.m.\n TU<\/jats:styled-content>\n (1000\u2009mg) or placebo.\n <\/jats:p>\n <\/jats:list-item>\n \n In all, 58 and 56 men in the placebo and treatment arm, respectively, completed the study.<\/jats:p>\n <\/jats:list-item>\n \n \n Participants were seen six times in the 48\u2010week period and the following data were collected: physical examination results, haemoglobin, haematocrit,\n TT<\/jats:styled-content>\n , lipid profile, fasting blood glucose, sex hormone\u2010binding globulin, liver function test, prostate\u2010 specific antigen (\n PSA<\/jats:styled-content>\n ) and adverse events.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n \n \n The mean (\n sd<\/jats:sc>\n ) age of the participants was 53.4 (7.6) years.\n <\/jats:p>\n <\/jats:list-item>\n \n \n A significant increase in serum\n TT<\/jats:styled-content>\n (\n P<\/jats:italic>\n < 0.001),\n PSA<\/jats:styled-content>\n (\n P<\/jats:italic>\n = 0.010), haematocrit (\n P<\/jats:italic>\n < 0.001), haemoglobin (\n P<\/jats:italic>\n < 0.001) and total bilirubin (\n P<\/jats:italic>\n = 0.001) were seen in the treatment arm over the 48\u2010week period.\n <\/jats:p>\n <\/jats:list-item>\n \n Two men in the placebo arm and one man in the treatment arm developed myocardial infarction.<\/jats:p>\n <\/jats:list-item>\n \n Common adverse events observed in the treatment arm included itching\/swelling\/pain at the site of injection, flushing and acne.<\/jats:p>\n <\/jats:list-item>\n \n \n Overall,\n TU<\/jats:styled-content>\n injections were well tolerated.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n \n \n TU<\/jats:styled-content>\n significantly increases serum testosterone in men with\n TD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n \n \n PSA<\/jats:styled-content>\n , haemoglobin and haematocrit were significantly elevated but were within clinically safe limits.\n <\/jats:p>\n <\/jats:list-item>\n \n There was no significant adverse reaction that led to the cessation of treatment.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12037","type":"journal-article","created":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T07:47:07Z","timestamp":1365752827000},"page":"1130-1140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Efficacy and safety of long\u2010acting intramuscular testosterone undecanoate in aging men: a randomised controlled study"],"prefix":"10.1111","volume":"111","author":[{"given":"Wei Shen","family":"Tan","sequence":"first","affiliation":[{"name":"Division 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Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Surgery University Kebangsaan Malaysia Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ee Ming","family":"Khoo","sequence":"additional","affiliation":[{"name":"Department of Primary Care Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology Gleaneagles Intan Medical Centre Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boon Cheok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology Sime Darby Medical Centre Kuala Lumpur 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