{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:26:36Z","timestamp":1790346396695,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T00:00:00Z","timestamp":1365724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2013,6]]},"abstract":"\n Objectives<\/jats:title>\n \n \n \n \n To assess the impact of lymphovascular invasion (\n LVI<\/jats:styled-content>\n ) on upper urinary tract urothelial carcinomas (\n UTUCs<\/jats:styled-content>\n ) in a multicentre study on cancer\u2010specific survival (\n CSS<\/jats:styled-content>\n ), recurrence\u2010free survival and metastasis\u2010free survival (\n MFS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:list-item>\n \n \n To show the negative impact of\n LVI<\/jats:styled-content>\n for patients with\n pN0<\/jats:styled-content>\n \/x disease and to stratify these patients into risk groups for metastatic relapse.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n \n \n A multicentre retrospective study was performed on patients who underwent radical nephroureterectomy between 1995 and 2010.<\/jats:p>\n <\/jats:list-item>\n \n \n LVI<\/jats:styled-content>\n status was evaluated as a prognostic factor for survival using univariate and multivariate\n C<\/jats:styled-content>\n ox regression analysis.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n \n \n Overall, 551 patients were included and were divided into two groups: those without\n LVI<\/jats:styled-content>\n (\n LVI<\/jats:styled-content>\n \u2212),\n n<\/jats:italic>\n \u2009=\u2009388 and those with\n LVI<\/jats:styled-content>\n (\n LVI<\/jats:styled-content>\n +),\n n<\/jats:italic>\n \u2009=\u2009163.\n <\/jats:p>\n <\/jats:list-item>\n \n \n LVI<\/jats:styled-content>\n + status was associated with high stage and grade\n UTUC<\/jats:styled-content>\n and lymph node metastasis (\n P<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:list-item>\n \n \n The 5\u2010year\n CSS<\/jats:styled-content>\n and\n MFS<\/jats:styled-content>\n rates were significantly worse in the\n LVI<\/jats:styled-content>\n + group than in\n LVI<\/jats:styled-content>\n \u2212 group (52.2 vs 84.5%,\n P<\/jats:italic>\n \u2009<\u20090.001 and 43.8 vs 82.7%,\n P<\/jats:italic>\n \u2009<\u20090.001, respectively).\n <\/jats:p>\n <\/jats:list-item>\n \n \n In multivariate analysis,\n LVI<\/jats:styled-content>\n + status was an independent prognostic factor for\n CSS<\/jats:styled-content>\n and\n MFS<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u2009=\u20090.04 and\n P<\/jats:italic>\n \u2009<\u20090.001). These findings were confirmed for the\n pN0<\/jats:styled-content>\n \/x patient subgroup (\n n<\/jats:italic>\n \u2009=\u2009504,\n P<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:list-item>\n \n \n In the\n pN0<\/jats:styled-content>\n \/x patient subgroup, we described a prognostic tool for\n MFS<\/jats:styled-content>\n based on independent factors that permitted us to stratify patients into groups of high, intermediate or low risk of metastasis relapse.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n \n \n The presence of\n LVI<\/jats:styled-content>\n was a strong predictor of a poor outcome for\n UTUC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n \n \n When a lymphadenectomy has not been achieved, the report of\n LVI<\/jats:styled-content>\n status is crucial to identfiy those patients at higher risk for metastatic relapse.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12116","type":"journal-article","created":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T07:48:44Z","timestamp":1365752924000},"page":"1199-1207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Impact of lymphovascular invasion on oncological outcomes in patients with upper tract urothelial carcinoma after radical nephroureterectomy"],"prefix":"10.1111","volume":"111","author":[{"given":"Sophie","family":"Hurel","sequence":"first","affiliation":[{"name":"Department of Urology C\u00f4te de Nacre Hospital CHU Caen Caen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Roupr\u00eat","sequence":"additional","affiliation":[{"name":"Department of Urology la Piti\u00e9 Salpetri\u00e8re Hospital AP\u2010HP 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