{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:07:56Z","timestamp":1789945676568,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T00:00:00Z","timestamp":1372118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            To investigate oncological outcomes and prognostic factors in patients with upper tract urothelial carcinoma (\n                            <jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content>\n                            ) who experienced disease recurrence after radical nephroureterectomy (\n                            <jats:styled-content style=\"fixed-case\">RNU<\/jats:styled-content>\n                            ).\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Few studies have focused on the clinical courses of patients who experienced disease recurrence after\n                            <jats:styled-content style=\"fixed-case\">RNU<\/jats:styled-content>\n                            .\n                          <\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            A total of 204\n                            <jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content>\n                            patients who experienced disease recurrence from a retrospective multi\u2010institutional cohort were included in the present study.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Associated patient outcomes were analyzed using multivariate analysis.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            The mean time from\n                            <jats:styled-content style=\"fixed-case\">RNU<\/jats:styled-content>\n                            to first disease recurrence was 15.0 months and \u224890% of patients experienced disease recurrence within the first 3 years after\n                            <jats:styled-content style=\"fixed-case\">RNU<\/jats:styled-content>\n                            .\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            During a median follow\u2010up of 8.1 month after disease recurrence, 165 patients died from\n                            <jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content>\n                            and five patients died from other causes. In the 204 cohorts, 1\u2010 and 3\u2010year cancer\u2010specific survival rates were 40.2% and 9.7%, respectively, and 1\u2010 and 3\u2010year overall survival rates were 39.5% and 9.4%, respectively.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>After disease recurrence, 132 patients underwent systemic chemotherapy, and a subgroup analysis of patients who underwent systemic chemotherapy multivariate analysis showed that performance status, the presence of liver metastasis and the number of recurrence sites were independently prognostic of cancer\u2010specific and overall survival after relapsing.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            According to three significant variables, 1\u2010 and 3\u2010year cancer\u2010specific survival rates were 72.7% and 20.8% in patients with no risk factors, 46.5% and 7.5% in patients with one risk factor, and 26.4% and 4.4% in patients with two or three risk factors, respectively (\n                            <jats:italic>P<\/jats:italic>\n                            &lt; 0.001).\n                          <\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            Most patients died from\n                            <jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content>\n                            within 3 years, even though systemic chemotherapies were administered after relapsing.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Multivariate analysis showed that performance status, the presence of liver metastasis and the number of recurrence sites were independently related to poor survival after systemic chemotherapy.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.12133","type":"journal-article","created":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T06:26:27Z","timestamp":1372141587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Patient characteristics and outcomes in metastatic upper tract urothelial carcinoma after radical nephroureterectomy: the experience of\n                    <scp>J<\/scp>\n                    apanese multi\u2010institutions"],"prefix":"10.1111","volume":"112","author":[{"given":"Nobuyuki","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Urology Keio University School of Medicine  Tokyo Japan"},{"name":"Department of Urology Musashino Yowakai Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Urology Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent","family":"Kanao","sequence":"additional","affiliation":[{"name":"Department of Urology Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Urology Keio University School of Medicine  Tokyo Japan"},{"name":"Department of Urology Saiseikai Central Hospital  Tokyo 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