{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:01:52Z","timestamp":1762506112796,"version":"build-2065373602"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,7]],"date-time":"2013-06-07T00:00:00Z","timestamp":1370563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2013,10]]},"abstract":"\n Objective<\/jats:title>\n \n \n \n \n To assess whether histological signs of inflammation are associated with an increased risk of subsequent prostate cancer (\n PCa<\/jats:styled-content>\n ) in men with elevated serum prostate\u2010specific antigen (\n PSA<\/jats:styled-content>\n ) concentrations and benign initial biopsy.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n \n \n \n Study subjects were men aged 54\u201367 years with an elevated\n PSA<\/jats:styled-content>\n (\u22654\u2009ng\/mL or 3\u20134\u2009ng\/mL and free to total\n PSA<\/jats:styled-content>\n ratio \u22640.16 or positive digital rectal examination), but a benign biopsy result within the\n F<\/jats:styled-content>\n innish population\u2010based randomised screening trial for\n PCa<\/jats:styled-content>\n , which started in 1996.\n <\/jats:p>\n <\/jats:list-item>\n \n \n A total of 293 prostate biopsies without\n PCa<\/jats:styled-content>\n or suspicion of malignancy from the first screening round in the\n T<\/jats:styled-content>\n ampere centre were re\u2010evaluated by a uropathologist to assess histological inflammation.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Results of the subsequent screening rounds were obtained from the trial database and\n PCa<\/jats:styled-content>\n diagnoses made outside the screening were obtained from the\n F<\/jats:styled-content>\n innish\n C<\/jats:styled-content>\n ancer\n R<\/jats:styled-content>\n egistry.\n <\/jats:p>\n <\/jats:list-item>\n \n The median length of follow\u2010up was 10.5 years.<\/jats:p>\n <\/jats:list-item>\n \n \n Cox regression analysis was used to assess\n PCa<\/jats:styled-content>\n risk after the initial benign biopsy.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n \n Histological inflammation was found in 66% of the biopsies.<\/jats:p>\n <\/jats:list-item>\n \n \n Subjects with inflammation at the biopsy had a slightly lower\n PCa<\/jats:styled-content>\n risk in the second screening round (18 vs 27%, rate ratio 0.69, 95% confidence interval [\n CI<\/jats:styled-content>\n ] 0.35\u20131.34) relative to men without inflammation. In further follow\u2010up, the\n PCa<\/jats:styled-content>\n risk remained nonsignificantly lower (hazard ratio [\n HR<\/jats:styled-content>\n ] 0.71,\n CI<\/jats:styled-content>\n 0.46\u20131.10;\n P<\/jats:italic>\n = 0.13). The risk was not appreciably affected by adjustment for age,\n PSA<\/jats:styled-content>\n , prostate volume and family history of\n PCa<\/jats:styled-content>\n (\n HR<\/jats:styled-content>\n 0.67,\n CI<\/jats:styled-content>\n 0.42\u20131.07;\n P<\/jats:italic>\n = 0.092).\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n \n \n Histological inflammation in a prostate biopsy among men with an initial false\u2010positive screening test was not associated with an increased risk of subsequent\n PCa<\/jats:styled-content>\n , but instead with a decreased risk which was of borderline significance.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Inflammation in prostate biopsy is not a useful risk indicator in\n PCa<\/jats:styled-content>\n screening.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12153","type":"journal-article","created":{"date-parts":[[2013,6,7]],"date-time":"2013-06-07T09:57:25Z","timestamp":1370599045000},"page":"735-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Histological inflammation and risk of subsequent prostate cancer among men with initially elevated serum prostate\u2010specific antigen (\n PSA<\/scp>\n ) concentration in the\n F<\/scp>\n innish prostate cancer screening trial"],"prefix":"10.1111","volume":"112","author":[{"given":"Tytti H.","family":"Yli\u2010Hemminki","sequence":"first","affiliation":[{"name":"Department of Pathology Fimlab Laboratories Tampere University Hospital Tampere"},{"name":"Department of Pathology Sein\u00e4joki Central Hospital Sein\u00e4joki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marita","family":"Laurila","sequence":"additional","affiliation":[{"name":"Department of Pathology Fimlab Laboratories Tampere University Hospital Tampere"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anssi","family":"Auvinen","sequence":"additional","affiliation":[{"name":"School of Health Sciences University of Tampere Tampere"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liisa","family":"M\u00e4\u00e4tt\u00e4nen","sequence":"additional","affiliation":[{"name":"Finnish Cancer Registry Helsinki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heini","family":"Huhtala","sequence":"additional","affiliation":[{"name":"School of Health Sciences University of Tampere Tampere"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teuvo L.J.","family":"Tammela","sequence":"additional","affiliation":[{"name":"Department of Urology Tampere University Hospital and University of Tampere Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula M.","family":"Kujala","sequence":"additional","affiliation":[{"name":"Department of Pathology Fimlab Laboratories Tampere University Hospital 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