{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T14:50:35Z","timestamp":1778165435767,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T00:00:00Z","timestamp":1374796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2013,11]]},"abstract":"\n Objectives<\/jats:title>\n \n \n \n \n To analyse the predictive factors for worse pathological outcome (muscle invasive\n pT2<\/jats:styled-content>\n +, non\u2010organ\u2010confined\n pT3<\/jats:styled-content>\n + or\n N<\/jats:styled-content>\n + and histological\n G<\/jats:styled-content>\n rade 3) of upper tract urothelial carcinoma (\n UTUC<\/jats:styled-content>\n ) in a\n C<\/jats:styled-content>\n hinese population from a nationwide high\u2010volume centre in\n C<\/jats:styled-content>\n hina.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n \n \n \n Predictors were studied by retrospectively reviewing the clinicopathological data of 729 consecutive patients with\n UTUC<\/jats:styled-content>\n treated in our centre from\n J<\/jats:styled-content>\n anuary 2002 to\n D<\/jats:styled-content>\n ecember 2010.\n <\/jats:p>\n <\/jats:list-item>\n \n Univariate and multivariate logistic regression analyses were used.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n \n There were more female patients (56.4%) than males and more tumours were located in the ureter (52.7%) than in the pelvis.<\/jats:p>\n <\/jats:list-item>\n \n \n In multivariate analysis, male gender (hazard ratio [\n HR<\/jats:styled-content>\n ] 1.898,\n P<\/jats:italic>\n = 0.001), sessile architecture (\n HR<\/jats:styled-content>\n 3.249,\n P<\/jats:italic>\n < 0.001), high grade (\n HR<\/jats:styled-content>\n 5.007,\n P<\/jats:italic>\n < 0.001), ipsilateral hydronephrosis (\n HR<\/jats:styled-content>\n 4.768,\n P<\/jats:italic>\n < 0.001), renal pelvis location (\n HR<\/jats:styled-content>\n 2.620,\n P<\/jats:italic>\n < 0.001) and tumour without multifocality (\n HR<\/jats:styled-content>\n 1.639,\n P<\/jats:italic>\n = 0.028) were predictive factors for muscle\u2010invasive\n UTUC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n \n \n Male gender (\n HR<\/jats:styled-content>\n 2.132,\n P<\/jats:italic>\n < 0.001), renal pelvis location (\n HR<\/jats:styled-content>\n 3.466,\n P<\/jats:italic>\n < 0.001), tumour without multifocality (\n HR<\/jats:styled-content>\n 2.532,\n P<\/jats:italic>\n = 0.001), sessile tumour architecture (\n HR<\/jats:styled-content>\n 3.274,\n P<\/jats:italic>\n < 0.001), and high grade (\n HR<\/jats:styled-content>\n 3.019,\n P<\/jats:italic>\n < 0.001) were predictive factors for non\u2010organ\u2010confined disease.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Chronological old age (\n HR<\/jats:styled-content>\n 1.047,\n P<\/jats:italic>\n < 0.001), sessile tumour architecture (\n HR<\/jats:styled-content>\n 25.192,\n P<\/jats:italic>\n < 0.001), ipsilateral hydronephrosis (\n HR<\/jats:styled-content>\n 1.689,\n P<\/jats:italic>\n = 0.024), and positive urinary cytology (\n HR<\/jats:styled-content>\n 1.997,\n P<\/jats:italic>\n = 0.006) were predictive factors for histological\n G<\/jats:styled-content>\n rade 3\n UTUC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n \n \n There was a predominance of female patients and ureteric tumours in\n UTUCs<\/jats:styled-content>\n of this\n C<\/jats:styled-content>\n hinese population.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Male gender, sessile architecture, tumour location, tumour without multifocality, high histological grade and preoperative ipsilateral hydronephrosis were independent predictive factors for worse pathological outcome of\n UTUCs<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12238","type":"journal-article","created":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T22:49:05Z","timestamp":1374878945000},"page":"917-924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Predictive factors for worse pathological outcomes of upper tract urothelial carcinoma: experience from a nationwide high\u2010volume centre in\n C<\/scp>\n hina"],"prefix":"10.1111","volume":"112","author":[{"given":"Xiao\u2010Peng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Urology Peking 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