{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:49:30Z","timestamp":1768322970332,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T00:00:00Z","timestamp":1374796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2013,10]]},"abstract":"\n Objective<\/jats:title>\n \n \n \n To compare the effectiveness of robot\u2010assisted and standard laparoscopic prostatectomy.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n \n \n A care pathway was described.<\/jats:p>\n <\/jats:list-item>\n \n \n We performed a systematic literature review based on a search of Medline, Medline in Process, Embase, Biosis, Science Citation Index, Cochrane Controlled Trials Register, Current Controlled Trials, Clinical Trials,\n WHO<\/jats:styled-content>\n International Clinical Trials Registry and\n NIH<\/jats:styled-content>\n Reporter, the Health Technology Assessment databases, the Database of Abstracts of Reviews of Effects, and relevant conference abstracts up to 31st\n O<\/jats:styled-content>\n ctober 2010). Additionally, reference lists were scanned, an expert panel consulted, and websites of manufacturers, professional organisations, and regulatory bodies were checked.\n <\/jats:p>\n <\/jats:list-item>\n \n \n We selected randomised controlled trials (\n RCTs<\/jats:styled-content>\n ) and non\u2010randomised comparative studies, published after 1st\n J<\/jats:styled-content>\n anuary 1995, including men with localised prostate cancer undergoing robot\u2010assisted or laparoscopic prostatectomy compared with the other procedure or with open prostatectomy. Studies where at least 90% of included men had clinical tumour stages\n T<\/jats:styled-content>\n 1 to\n T<\/jats:styled-content>\n 2 and which reported at least one of our specified outcomes were eligible for inclusion.\n <\/jats:p>\n <\/jats:list-item>\n \n A mixed\u2010treatment comparison meta\u2010analysis was performed to generate comparative statistics on specified outcomes.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n \n \n We included data from 19\u2009064 men across one\n RCT<\/jats:styled-content>\n and 57 non\u2010randomised comparative reports.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Robotic prostatectomy had a lower risk of major intra\u2010operative harms such as organ injury [0.4% robotic vs 2.9% laparoscopic], odds ratio ([\n OR<\/jats:styled-content>\n ] {95% credible interval [\n CrI<\/jats:styled-content>\n ]} 0.16 [0.03 to 0.76]), and a lower rate of surgical margins positive for cancer [17.6% robotic vs 23.6% laparoscopic],\n OR<\/jats:styled-content>\n [95%\n CrI<\/jats:styled-content>\n ] 0.69 [0.51 to 0.96]). There was no evidence of a difference in the proportion of men with urinary incontinence at 12 months (\n OR<\/jats:styled-content>\n [95%\n CrI<\/jats:styled-content>\n ] 0.55 [0.09 to 2.84]). There were insufficient data on sexual dysfunction.\n <\/jats:p>\n <\/jats:list-item>\n \n Surgeon learning rates for the procedures did not differ, although data were limited.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n \n Men undergoing robotic prostatectomy appear to have reduced surgical morbidity, and a lower risk of a positive surgical margin, which may reduce rates of cancer recurrence and the need for further treatment, but considerable uncertainty surrounds these results.<\/jats:p>\n <\/jats:list-item>\n \n We found no evidence that men undergoing robotic prostatectomy are disadvantaged in terms of early outcomes.<\/jats:p>\n <\/jats:list-item>\n \n We were unable to determine longer\u2010term relative effectiveness.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12247","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T12:21:53Z","timestamp":1369311713000},"page":"798-812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Relative effectiveness of robot\u2010assisted and standard laparoscopic prostatectomy as alternatives to open radical prostatectomy for treatment of localised prostate cancer: a systematic review and mixed treatment comparison meta\u2010analysis"],"prefix":"10.1111","volume":"112","author":[{"given":"Clare","family":"Robertson","sequence":"first","affiliation":[{"name":"Health Services Research Unit University of Aberdeen Aberdeen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Close","sequence":"additional","affiliation":[{"name":"School of Biology Newcastle University Newcastle\u2010upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Fraser","sequence":"additional","affiliation":[{"name":"Health Services Research Unit University of Aberdeen Aberdeen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Gurung","sequence":"additional","affiliation":[{"name":"Health Services Research Unit University of Aberdeen Aberdeen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueli","family":"Jia","sequence":"additional","affiliation":[{"name":"Health Services Research Unit University of Aberdeen Aberdeen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawana","family":"Sharma","sequence":"additional","affiliation":[{"name":"Health Services Research Unit University of Aberdeen Aberdeen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke","family":"Vale","sequence":"additional","affiliation":[{"name":"Institute of Health and Society Newcastle University Newcastle\u2010upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Ramsay","sequence":"additional","affiliation":[{"name":"Health Services Research Unit University of Aberdeen Aberdeen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Pickard","sequence":"additional","affiliation":[{"name":"Institute of Cellular Medicine Newcastle University Newcastle\u2010upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,26]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"LaveryHJ SamadiDB LeveilleeRJ.Not a zero\u2010sum game: the adoption of robotics has increased overall prostatectomy utilisation in the United States[document on the Internet]. 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