{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:37:49Z","timestamp":1761748669210,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T00:00:00Z","timestamp":1376352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2014,1]]},"abstract":"\n Objective<\/jats:title>\n \n \n \n \n To evaluate oncological outcomes of patients with carcinoma\n in situ<\/jats:italic>\n (\n CIS<\/jats:styled-content>\n ) exclusively at radical cystectomy (\n RC<\/jats:styled-content>\n ) and no previous history of\u2009\u2265\n T<\/jats:styled-content>\n 1 disease.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n \n \n \n Patients undergoing\n RC<\/jats:styled-content>\n with curative intent for\n CIS<\/jats:styled-content>\n between 1971 and 2008 at the\n U<\/jats:styled-content>\n niversity of\n S<\/jats:styled-content>\n outhern\n C<\/jats:styled-content>\n alifornia were included if they met all the following criteria: (i) pathological\n CIS<\/jats:styled-content>\n \u2010only disease at\n RC<\/jats:styled-content>\n , (ii) preoperative clinical stage\n cCIS<\/jats:styled-content>\n and\/or\n cCIS<\/jats:styled-content>\n \u2009+\u2009\n cTa<\/jats:styled-content>\n , and (iii) no previous history of lamina propria invasion (\u2265\n pT1<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:list-item>\n \n \n Kaplan\u2013\n M<\/jats:styled-content>\n eier plots were used to estimate the probabilities of recurrence\u2010free survival (\n RFS<\/jats:styled-content>\n ) and overall survival (\n OS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n \n Of the 1964 consented patients 52 met the inclusion criteria with a median (range) follow\u2010up of 8.5 (0.008\u201334) years.<\/jats:p>\n <\/jats:list-item>\n \n A median (range) of 36 (10\u201395) lymph nodes were identified per patient but no metastases found.<\/jats:p>\n <\/jats:list-item>\n \n \n Estimated 5\u2010 and 10\u2010year\n RFS<\/jats:styled-content>\n rates were 94% and 90%, respectively and estimated 5\u2010 and 10\u2010year\n OS<\/jats:styled-content>\n rates were 85% and 66%, respectively.\n <\/jats:p>\n <\/jats:list-item>\n \n Different mechanisms of recurrence were found in four (8%) patients after a median (range) interval of 2.4 (0.6\u20137.1) years. While two patients had metachronous recurrence within the urinary tract, the first of the other two had early systemic recurrence and the second late local recurrence.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n \n \n We noticed excellent outcomes after\n RC<\/jats:styled-content>\n for\n CIS<\/jats:styled-content>\n \u2010only disease.\n <\/jats:p>\n <\/jats:list-item>\n \n However, patients may have synchronous and\/or develop metachronous tumours, as well as local and\/or distant\/systemic recurrence that can be cured but may also lead to fatal outcomes.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12250","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T12:23:06Z","timestamp":1369311786000},"page":"65-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Outcome in patients with exclusive carcinoma\n in situ<\/i>\n (\n CIS<\/scp>\n ) after radical cystectomy"],"prefix":"10.1111","volume":"113","author":[{"given":"Pascal","family":"Zehnder","sequence":"first","affiliation":[{"name":"Catherine & Joseph Aresty Department of Urology USC Institute of Urology Los Angeles CA USA"},{"name":"Department of Urology University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Moltzahn","sequence":"additional","affiliation":[{"name":"Department of Urology University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siamak","family":"Daneshmand","sequence":"additional","affiliation":[{"name":"Catherine & Joseph Aresty Department of Urology USC Institute of Urology Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marya","family":"Leahy","sequence":"additional","affiliation":[{"name":"Catherine & Joseph Aresty Department of Urology USC Institute of Urology Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Cai","sequence":"additional","affiliation":[{"name":"Catherine & Joseph Aresty Department of Urology USC Institute of Urology Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gus","family":"Miranda","sequence":"additional","affiliation":[{"name":"Catherine & Joseph Aresty Department of Urology USC Institute of Urology Los Angeles CA 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inderbir S.","family":"Gill","sequence":"additional","affiliation":[{"name":"Catherine & Joseph Aresty Department of Urology USC Institute of Urology Los Angeles CA 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