{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:32:02Z","timestamp":1789871522353,"version":"4.0.1"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T00:00:00Z","timestamp":1402012800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2014,6]]},"abstract":"\n Objective<\/jats:title>\n \n \n \n \n To study the unique characteristics of erectile dysfunction (\n ED<\/jats:styled-content>\n ) in a population of men who developed\n ED<\/jats:styled-content>\n after testicular cancer (\n TC<\/jats:styled-content>\n ) diagnosis and treatment.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n \n \n \n All men treated for\n TC<\/jats:styled-content>\n who presented for sexual function evaluation were included in an institutional database.\n <\/jats:p>\n <\/jats:list-item>\n \n \n All men underwent standard evaluation including a history\/physical examination, completion of the\n I<\/jats:styled-content>\n nternational\n I<\/jats:styled-content>\n ndex of\n E<\/jats:styled-content>\n rectile\n F<\/jats:styled-content>\n unction (\n IIEF<\/jats:styled-content>\n ) questionnaire, testosterone\/gonadotropin measurement and penile duplex\n D<\/jats:styled-content>\n oppler ultrasonography (\n DUS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n \n \n The study population comprised 76 men whose mean (\n sd<\/jats:sc>\n ) age was 29 (8) years and of whom 25% were married\/had a partner. In all, 39% of the patients had seminoma and 61% had non\u2010seminomatous germ\u2010cell tumour (\n NSGCT<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:list-item>\n \n \n A total of 66% of patients with seminoma underwent radiation therapy. Of the patients with\n NSGCT<\/jats:styled-content>\n , 79% received chemotherapy, 18% underwent primary retroperitoneal lymph node dissection (\n RPLND<\/jats:styled-content>\n ) and 20% underwent post\u2010chemotherapy\n RPLND<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n \n \n The mean (\n sd<\/jats:sc>\n ) time before seeking sexual medicine consultation was 12 (7) months after treatment completion, the median (range) number of vascular risk factors was 0 (0\u20132) and the mean (\n sd<\/jats:sc>\n ) remaining testis volume was 16 (8) mL. Mean (\n sd<\/jats:sc>\n ) total testosterone, luteinizing hormone, follicle\u2010stimulating hormone levels were 312 (186) ng\/dL, 9 (7) IU\/mL, 17 (12) IU\/mL. A total of 26% of patients had total testosterone levels <300\u2009ng\/dL.\n <\/jats:p>\n <\/jats:list-item>\n \n \n In all, 84% of patients complained primarily of loss of erection\u2010sustaining capability and 24% had episodes of transient\n ED<\/jats:styled-content>\n before\n TC<\/jats:styled-content>\n diagnosis. The mean (\n sd<\/jats:sc>\n )\n IIEF<\/jats:styled-content>\n erectile function domain score was 16 (7).\n <\/jats:p>\n <\/jats:list-item>\n \n \n All the patients (100%) had a normal\n DUS<\/jats:styled-content>\n . Mean (\n sd<\/jats:sc>\n ) peak systolic and end\u2010diastolic velocities were 48 (16) and 1.2 (2.2) cm\/s, respectively.\n <\/jats:p>\n <\/jats:list-item>\n \n \n A total of 88% of patients responded to phosphodiesterase type 5 inhibitor (\n PDE<\/jats:styled-content>\n 5i) use with erections sufficient for penetration, but 12% did not (mean [\n sd<\/jats:sc>\n ] erectile function domain score 27 [5] vs 17 [6]).\n <\/jats:p>\n <\/jats:list-item>\n \n There were no differences in haemodynamics between those men with and without hypogonadism.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n \n \n Men with\n TC<\/jats:styled-content>\n presenting with\n ED<\/jats:styled-content>\n after treatment appear uniformly to have normal erectile haemodynamics, suggesting adrenaline\u2010mediated\n ED<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n \n \n While the majority of\n TC<\/jats:styled-content>\n survivors with\n ED<\/jats:styled-content>\n respond successfully to\n PDE<\/jats:styled-content>\n 5i, a significant minority do not.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12331","type":"journal-article","created":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T09:07:15Z","timestamp":1372324035000},"page":"907-910","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Erectile dysfunction in men treated for testicular cancer"],"prefix":"10.1111","volume":"113","author":[{"given":"Raanan","family":"Tal","sequence":"first","affiliation":[{"name":"Male Sexual and Reproductive Medicine Program Urology Service Department of Surgery Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron S.","family":"Stember","sequence":"additional","affiliation":[{"name":"Male Sexual and Reproductive Medicine Program Urology Service Department of Surgery Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Logmanieh","sequence":"additional","affiliation":[{"name":"Male Sexual and Reproductive Medicine Program Urology Service Department of Surgery Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Narus","sequence":"additional","affiliation":[{"name":"Male Sexual and Reproductive Medicine Program Urology Service Department of Surgery Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Mulhall","sequence":"additional","affiliation":[{"name":"Male Sexual and Reproductive Medicine Program Urology Service Department of Surgery Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,6]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Surveillance Epidemiology and End Results (SEER) Program.Surveillance Epidemiology and End Results (SEER) \u2013 Cancer Statistics 2004\u20132008.2011. 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