{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:46:06Z","timestamp":1771328766884,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T00:00:00Z","timestamp":1396483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2014,8]]},"abstract":"\n Objective<\/jats:title>\n \n \n \n \n To compare overall and cancer\u2010specific outcomes between patients with upper tract urothelial carcinoma (\n UTUC<\/jats:styled-content>\n ) managed with either radical nephroureterectomy (\n RNU<\/jats:styled-content>\n ) or nephron\u2010sparing measures (\n NSM<\/jats:styled-content>\n ) using a large population\u2010based dataset.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n \n \n \n Using Surveillance, Epidemiology, and End Results (\n SEER<\/jats:styled-content>\n ) data, patients diagnosed with low\u2010 or moderate\u2010grade, localised non\u2010invasive\n UTUC<\/jats:styled-content>\n were stratified into two groups: those treated with\n RNU<\/jats:styled-content>\n or\n NSM<\/jats:styled-content>\n (observation, endoscopic ablation, or segmental ureterectomy).\n <\/jats:p>\n <\/jats:list-item>\n \n \n Cancer\u2010specific mortality (\n CSM<\/jats:styled-content>\n ) and other\u2010cause mortality (\n OCM<\/jats:styled-content>\n ) rates were determined using cumulative incidence estimators. Adjusting for clinical and pathological characteristics, the associations between surgical type, all\u2010cause mortality and\n CSM<\/jats:styled-content>\n were tested using Cox regressions and Fine and Gray regressions, respectively.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n \n \n Of 1227 patients [mean (\n sd)<\/jats:sc>\n age 70.2 (11.00) years, 63.2% male] meeting inclusion criteria, 907 (73.9%) and 320 (26.1%) patients underwent\n RNU<\/jats:styled-content>\n and\n NSM<\/jats:styled-content>\n for low\u2010 or moderate\u2010grade, low\u2010stage\n UTUC<\/jats:styled-content>\n from 1992 to 2008.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Patients undergoing\n NSM<\/jats:styled-content>\n were older (mean age 71.6 vs 69.7 years,\n P<\/jats:italic>\n < 0.01) with a greater proportion of well\u2010differentiated tumours (26.3% vs 18.0%,\n P<\/jats:italic>\n = 0.001).\n <\/jats:p>\n <\/jats:list-item>\n \n \n While there were differences in\n OCM<\/jats:styled-content>\n between the groups (\n P<\/jats:italic>\n < 0.01),\n CSM<\/jats:styled-content>\n trends were equivalent. After adjustment,\n RNU<\/jats:styled-content>\n treatment was associated with improved non\u2010cancer cause survival [hazard ratio (\n HR<\/jats:styled-content>\n ) 0.78, confidence interval [\n CI<\/jats:styled-content>\n ] 0.64\u20130.94) while no association with\n CSM<\/jats:styled-content>\n was demonstrable (\n HR<\/jats:styled-content>\n 0.89,\n CI<\/jats:styled-content>\n 0.63\u20131.26).\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n \n \n Patients with low\u2010 or moderate\u2010grade, low\u2010stage\n UTUC<\/jats:styled-content>\n managed through\n NSM<\/jats:styled-content>\n are older and are more likely to die of other causes, but they have similar\n CSM<\/jats:styled-content>\n rates to those patients managed with\n RNU<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n \n \n These data may be useful when counselling patients with\n UTUC<\/jats:styled-content>\n with significant competing comorbidities.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12341","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T10:10:25Z","timestamp":1372759825000},"page":"216-220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Nephron\u2010sparing management vs radical nephroureterectomy for low\u2010 or moderate\u2010grade, low\u2010stage upper tract urothelial carcinoma"],"prefix":"10.1111","volume":"114","author":[{"given":"Jay","family":"Simhan","sequence":"first","affiliation":[{"name":"Division of Urologic Oncology Departments of Surgical Oncology Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc C.","family":"Smaldone","sequence":"additional","affiliation":[{"name":"Division of Urologic Oncology Departments of Surgical Oncology Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian L.","family":"Egleston","sequence":"additional","affiliation":[{"name":"Biostatistics Fox Chase Cancer Center Temple University School of Medicine Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Canter","sequence":"additional","affiliation":[{"name":"Department of Urology Emory University School of Medicine Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven N.","family":"Sterious","sequence":"additional","affiliation":[{"name":"Division of Urologic Oncology Departments of Surgical Oncology Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony T.","family":"Corcoran","sequence":"additional","affiliation":[{"name":"Division of Urologic Oncology Departments of Surgical Oncology Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Ginzburg","sequence":"additional","affiliation":[{"name":"Division of Urologic Oncology Departments of Surgical Oncology Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Uzzo","sequence":"additional","affiliation":[{"name":"Division of Urologic Oncology Departments of Surgical Oncology Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Kutikov","sequence":"additional","affiliation":[{"name":"Division of Urologic Oncology Departments of Surgical Oncology Philadelphia PA 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